摘要
多中心观察室上性心律失常309例。国产艾司洛尔静脉注射治疗室上性心律失常共225例,总有效率为74.6%,其中49例随机分组与进口艾司洛尔比较;另35例随机分层与美托洛尔比较,总有效率相接近。国产艾司洛尔治疗室上性心律失常的疗效确切。窦性心动过速时,艾司洛尔的治疗反应最佳,异位性室上性心律失常中,约1/3病例用药后转复为窦性心律,一般可使心室率减慢。大多数患者对国产艾司洛尔耐受良好,不良反应发生率为6.2%。个别患者出现恶心、胸闷、出汗、心悸。低血压发生率为4.0%。
To evaluate the antiarrythmic effect and safetiness of esmolol,we observed 309 patients with supraventrtcular tachyarrthma from δ medical centers,including atria fibrillation or flutter.paroxysmal supraveotricular tachycardta.automatic atria tachycardia,sious tachycardia fnoocompensated,requtred treatment,ventricular heart rate≥120 bpm>and sinus tachycardia in the perioperative period(heart rateè100 bpm).Test esmolol group(Qilu Pharmaceutical Co,)tocluded235 cases,cootrolled esmolol group(DU Pont Pharmaceutical Co.).49 cases,and controlled metuprclol group.35 cases,according to the kiod of arrythmia,a randomized paracootrolled,singte-bliodstudy was performed,In the test esmolol group.74.6%of the cases achieved good therapeuttcal respcnse(defined as ventricular heart rate<<100 bpm,or>20"<reductton in the average baseline heartratr,or reversion to normal sinus rhythm).The therapeutie response was similar to that of the twocon:rolled groups.Best therapeuttc response exhibited tm the patients with stnus tachycardia(87.5i).1/3 cases of ectopic arrythmia reversed to normal sinus rhythm.Most of the patrents inthe test esmotol group tolerated well.The adverse reaction exhibited in 6.32%of patients who re-ceived test esmolol being hypotension(4,0%),nausea,sweeting.palpitatton.depresstng feeling tnthe chest.The results showed that tbe effect of intravenous eamolot for the treatment ofsupraventricular tachyarrythymia is definite and safe.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1996年第6期404-407,共4页
Chinese Journal of Cardiology
