摘要
用细胞内微电极和微机实时分析技术发现:关附甲素(Guan-fu base A,GFA)能使豚鼠心室乳头肌动作电位的Vmax和APA降低,RP无明显影响。动作电位时程缩短,以上作用具有浓度依赖性:ERP相对延长;对北草乌头碱引起的自发节律有明显抑制作用。
The effects of Guan-fu base A(GFA) on ventricular papillary muscles of guinea pigs were studied using glass-microelectrode technique and microcomputer on-line analysis. GFA could reduce the action potential amplititude, maximum rate of depolarization and action potential duration in a concentration-dependent manner, but had less effect on the resting potential. The effective refractory period was relatively prolonged. GFA could also inhibit the arrhythmogenic action of Beiwutine.
出处
《上海第二医科大学学报》
CSCD
1989年第2期105-108,共4页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
关附甲素
北草鸟头碱
抗心律失常药
GFA antiarrhythmic agents action potentials Beiwutine
