摘要
目的:探讨帕罗西汀对应激抑郁模型大鼠海马锥体神经元的保护作用。方法:强迫大鼠游泳4周建立抑郁模型。用Nissl染色观察海马CA1和CA3区锥体神经元的形态。结果:用药4周(Ⅵ)组的大鼠海马CA1区锥体神经元的计数显著高于其他各组(P<0.05或P<0.01)。在CA3区,模型组、用药1次组和用药1周组海马锥体神经元计数均显著少于对照(Ⅰ)组(P<0.05),用药2周组与Ⅰ组比无统计学意义(P>0.05),Ⅵ组CA3区神经元计数显著高于Ⅰ组(P<0.05)。结论:帕罗西汀长期用药对慢性应激抑郁模型大鼠的海马锥体神经元的存活具有保护作用。
Objective： To study the protective effect of paroxetine on the pyramidal neurons in hippoeampus of rots of depressed model. Methods： Depressed model was forced rats to swim for four weeks. Nissl staining was used to observe the survival of the pyramidal neurons in hippocampal CA1 and C, A3 regions. Results： The amount of neurons in CA1 region in group of paroxetine-treated for four weeks（group Ⅵ ）was significantly more than that of other groups （P 〈 0.05 or P 〈 0.01）, The amount of neurons in CA3 region of depressed model group, group of paroxetine-treated once and group of paroxetine-treated for one week was significantly less than that of control group（group Ⅰ ）（ P 〈 0.05）. There was no significant difference between group paroxetine-treated for two weeks and group Ⅰ （ P 〉 0.05）. The amount of neurons in C, A3 region of group Ⅵ was significantly more than that of group Ⅰ （ P 〈 0.05）. Conclusion： Chronic administration of paroxetine can improve the survival ability of the pyramidal neurons in hippocampal CA1 and C, A3 regions of rots of depressed model.
出处
《汕头大学医学院学报》
2006年第3期148-150,F0003,共4页
Journal of Shantou University Medical College
关键词
帕罗西汀
抑郁
海马
Nid染色
paroxetine
depression
hippocampus
Nissl staining
