摘要
目的:为了探讨更年期妇女抑郁症状与血清孕激素、叶酸、五羟色胺的相关性,寻求有效的预防和治疗措施。方法:采用自我评定抑郁量表(SDS)或抑郁状态调查问卷(DSI)对长春市部分企事业单位的围绝经期及绝经后的更年期妇女进行抑郁症状的评价;采用病例对照方法,应用放射免疫测定方法和荧光法对更年期抑郁组、更年期正常组和生育年龄期正常对照组妇女各30例进行血清孕激素、叶酸、五羟色胺测定。结果:更年期抑郁组的血清孕酮水平高于更年期正常组,且均低于正常生育期妇女;更年期抑郁组血清叶酸、五羟色胺水平均低于更年期正常组和正常生育期妇女;更年期血中孕激素与五羟色胺的水平呈负相关,血中叶酸与五羟色胺水平呈正相关。结论:更年期妇女抑郁症状的发生与血清孕激素水平、低叶酸及五羟色胺水平有关。
Objective ： To explore the relativity of the depression symptom in climacteric women to the levels of serum progestogen, folate and serotonin to explore the effective prevention and treatment measurements. Methods： With the application of the depression status inventory （DSI） or the self depression scale the perimenopausal and menopausal women （ menopaused 1 - 3 years） between 40 and 55 years old in several communities and charities of the Changchun city were investigated to evaluate the symptom of depression by case - control method to test the serum progestogen, folate and serotonin of the climacteric women with depression, normal climacteric women and normal reproductive women 30 irrespectively, by means of radioimmunoassay and fluorescence method. Results： The level of serum progestogen （ 14. 149 ng/ml） of the climacteric women with depression was higher than the one of the normal climacteric women （7.709 ng/ml） , and they were all lower than those of normal reproductive women （21. 328 ng/ml） . The level of serum folate （7. 480 ng/ml） and the level of serum serotonin （0. 160 μg/ml） of the climacteric women with depression were lower than those of normal climacteric women （9. 980 ng/ml and 0. 209 μg/ml） and the normal reproductive women （9. 267 ng/ml and 0. 193μg/ml） ; the level of serum progestogen was negatively related to the level of serum serotonin; the level of serum folate is positively related to the level of serum serotonin in climacteric women. Conclusion： The onset of the depression symptom in the climacteric women was related to the level of the serum progestogen, and was also related to the low serum folate and serotonin levels.
出处
《中国妇幼保健》
CAS
北大核心
2006年第17期2433-2436,共4页
Maternal and Child Health Care of China
关键词
更年期
抑郁
孕激素
叶酸
五羟色胺
Climacterium
Depression
Progestogen
Folate
Serotonin
