摘要
目的观察自行研制的中草药液体型药贴(CHDLP)对动物皮肤的毒性作用。方法用该药贴在健康豚鼠身上进行急性皮肤刺激试验、多次皮肤刺激试验与皮肤变态反应试验。结果急性皮肤刺激反应积分值及皮肤刺激强度积分值均为0；多次皮肤刺激试验刺激指数及病理组织检查积分均为0；变态反应积分值及致敏率亦均为0。结论CHDLP对豚鼠皮肤无刺激性,属弱致敏物。外用CHDLP较安全。
Objective To study the animal toxicity test on skin of the Chinese herbal drugs liquid paste （CHDLP）. Methods AcuTe and multiple times skin stimulation test and skin allergy test were performed on healthy guinea pig by using CHDLP. Results The acute skin stimulation score and intensity score were all zero. Multiple skin stimulation score and pathological examination score were all zero. So were the skin allergy score and the sensitization rate. Conclusion CI-tDLP is a weak sensitizer and arose no skin stimulation on guinea pig. It＇ s safe when external use.
出处
《中国基层医药》
CAS
2006年第8期1237-1238,共2页
Chinese Journal of Primary Medicine and Pharmacy
基金
广东省科技计划项目基金资助(2002A3010303)
珠海市科技计划项目基金资助(PC200310062)
珠海市医学科研基金资助(2002A3010303
配套)
广东省中医药局科研基金资助(101141)
