摘要
目的:寻找出生缺陷高发区病人体内含量异常的元素,为出生缺陷的干预和治疗提供理论依据。方法:在病区分别采集有出生缺陷儿童和健康儿童头发样品,经预处理后,采用ICP-电感耦合等离子发射光谱法,对16种元素进行了测定,所得数据采用SPSS 10.0进行非参数检验和多元回归分析。结果:与健康儿童头发样品相比,患儿发中Mo,Zn,Sr,Fe,Mg,Ca等含量显著偏低,V偏高;以病情为因变量,发中16种元素含量为自变量经逐步回归分析,有Mo,Zn,Ni等进入方程。提示该区病人体内Mo,Zn等含量低、Ni含量高与病情有关。结论:Mo,Zn等在人体内的缺乏可能是出生缺陷发生的重要因素,Sr,K,Cu,Sn,Mg,Se,Fe,Ca等含量偏低及V含量偏高可能与Mo,Zn,Ni等共同起到协同致病的作用。
Objective： To find elements of abnormal concentration in hair of patients with birth defects in order to afford gist for preventing and curing diseases. Methods： Some hair was sampled from patients and healthy people respectively in disease region, and then the concentrations of 16 kinds of elements were measured with ICP machine and the data was analyzed with regression and nonparametric tests. Results： The content of Mo, Zn, Sr, Fe, Mg, Ca is significantly low in hair of patients, but V has significantly high content. The result of stepwise linear regression is that Mo, Zn and Ni have been selected into the equation. Conclusion： the low concentrations of Mo, Zn and high content of V in patients might have relationship to birth defects, besides, it is possible that there is synergistic effects between Sr, K, Cu, Sn, Mg, Se, Fe, Ca, V and Mo, Zn, Ni for the occurance of birth defects.
出处
《广东微量元素科学》
CAS
2006年第8期23-26,共4页
Trace Elements Science
基金
国家重点基础研究发展规划项目(2001CB510305)
关键词
山西省
出生缺陷
微量元素
协同作用
Shanxi province
birth defects
trace element
synergistic effect
