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HLA与HPV相关肿瘤的研究进展 被引量：3

Progression of HLA and HPV-related tumors
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摘要 人乳头状瘤病毒(HPV)感染是宫颈癌等肿瘤的高危因素,其致瘤机制尚未完全阐明。在免疫应答过程中,机体HLA-I,Ⅱ,Ⅲ类分子表达异常与HPV相关肿瘤免疫逃避有关,可为宫颈癌、食管癌等肿瘤的病因学提供新的线索。 Human papillomavirus （HPV） infection is a high risk factor of cervical carcinoma. The pathogenesis of HPV infection is incompletely elucidated. Human leukocyte antigen （HLA） is the greatest complicated immune system. The evaluation of associations of HLA alleles with HPV variants may be helpful in designing vaccines capable of mediating immune protection against HPV infection. It can offer new clues for the etiology of carcinoma that the abnormal expressions of HLA class Ⅰ, Ⅱ and Ⅲ molecules are relate to the immune escape of HPV-related carcinoma during immune response.
作者 杨兰 孙振柱 李锋
机构地区 新疆石河子医学院病理教研室 新疆维吾尔自治区人民医院病理科
出处 《国际病理科学与临床杂志》 CAS 2006年第4期321-324,共4页 Journal of International Pathology and Clinical Medicine
基金 973重大基础研究前期专项(2005CCA03700) 教育部高校创新工程重大项目培育资金(2061667)
关键词 HLA HPV 宫颈癌 食管癌 免疫逃避 HLA HPV cervical carcinoma esophageal carcinoma immune escape
分类号 R730.23 [医药卫生—肿瘤]
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参考文献23

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二级参考文献10

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国际病理科学与临床杂志
2006年 第4期

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