期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

BNIP3基因及其与肿瘤的关系 被引量：5

BNIP3 gene and its relationship with tumor
暂未订购
导出
摘要 BNIP3是bc l-2家族中BH3-on ly亚家族的成员,具有BH3结构域和跨膜区,属于促凋亡蛋白。BNIP3通过促进线粒体通透性转运孔开放和线粒体的损伤诱导凋亡,其表达受缺氧和其他因素的影响。近年研究发现BNIP3的表达异常和许多肿瘤的进展及耐药性有关。 BNIP3, a member of BH3-only subfamily of bcl-2 superfamily, which has a BH3 domain and a trans-membrane domain, belongs to pro-apoptotic proteins. BNIP3 mediates apoptosis through mitochondrial permeability transport pore opening and mitochondrial dysfunction. The expression of BNIP3 is regulated by hypoxia and other factors. Studies have shown that abnormal expression of BNIP3 is correlated with the progression and drug-resistance of many tumors in recent years.
作者 谢晋予 郑长黎
机构地区 中南大学湘雅医学院病理学系
出处 《国际病理科学与临床杂志》 CAS 2006年第4期298-301,共4页 Journal of International Pathology and Clinical Medicine
关键词 BNIP3 凋亡 肿瘤 BNIP3 apoptosis tumor
分类号 R730.231 [医药卫生—肿瘤]
  • 相关文献

参考文献26

  • 1Yasuda M,Theodorakis P,Subramanian T,et al.Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence[J].J Biol Chem,1998,273(20):12415-12421.
  • 2Guo K,Searfoss G,Krolikowski D,et al.Hypoxia induces the expression of the pro-apoptotic gene BNIP3[J].Cell Death Differ,2001,8(4):367-376.
  • 3Bruick RK.Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia[J].Proc Natl Acad Sci USA,2000,97(16):9082-9087.
  • 4Lee SD,Kuo WW,Wu CH,et al.Effects of short-and long-term hypobaric hypoxia on Bcl2 family in rat heart[J].Int J Cardial,2006,108 (3):376-384.
  • 5Zamora R,Alarcon L,Vodovotz Y,et al.Nitric oxide suppresses the expression of Bcl-2 binding protein BNIP3 in hepatocytes[J].J Biol Chem,2001,276 (50):46887-46895.
  • 6Yook YH,Kang KH,Maeng O,et al.Nitric oxide induces BNIP3 expression that causes cell death in macrophages[J].Biochem Biophys Res Commun,2004,321 (2):298-305.
  • 7Mizutani A,Furukawa T,Adachi Y,et al.A zinc-finger protein,PLAGL2,induces the expression of a proapoptotic protein Nip3,leading to cellular apoptosis[J].J Biol Chem,2002,277 (18):15851-15858.
  • 8Kothari S,Cizeau J,McMillan-Ward E,et al.BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF[J].Oncogene,2003,22 (30):4734-4744.
  • 9Baetz D,Regula KM,Ens K,et al.Nuclear factor-kappaB-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes[J].Circulation,2005,112(24):3777-3785.
  • 10Sohn SJ,Li D,Lee LK,et al.Transcriptional regulation of tissuespecific genes by the ERK5 mitogen-activated protein kinase[J].Mol Cell Biol,2005,25 (19):8553-8566.

同被引文献56

  • 1沈雁峰,孙殿军,赵新华,于光前.中国饮水型地方性砷中毒病区和高砷区水砷筛查报告[J].中国地方病学杂志,2005,24(2):172-175. 被引量：49
  • 2马艳（综述）,郑玉建（审校）,吴顺华（审校）.砷对神经系统损伤的研究进展[J].中国地方病学杂志,2007,26(1):111-113. 被引量：8
  • 3YasudaM, Theodorakis P, Subramanian T, et al. Adenovirus E1B19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence[J]. J Biol Chem, 1998(20) :12415 - 12421.
  • 4Guo K, Searfoss G, Krolikowski D, et al. Hypoxia induces the expression of the pro-apoptotic gene BNIP3 [ J ]. Cell Death Differ, 2001 ( 4 ) : 367 - 376.
  • 5Yook YH, Kang KH, Maeng O, et al. Nitric oxide induces BNIP3 expression that causes cell death in macrophages[J]. Biochem Biophys Res Commun, 2004 (2) : 298 - 305.
  • 6Burton TR, Henson ES, Baijal P, et al. The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastomamultiforme tumor cell survival under hypoxia[ J ]. Int J Cancer, 2006 (7) : 1660 - 1669.
  • 7Giatromanolaki A, KoukourakisMI, Sowter HM, et al. BNIP3 expression is linked with hypoxia regulated protein expression and with poor prognosis in non-small cell lung cancer[J]. Clin Cancer Res,2004(16) :5566 - 5571.
  • 8Akada M, Crnogorae-Jureevie T, Lattimore S, et al. Intrinsic ehemoresistance to gemeitabine is associated with deereased expression of BNIP3 in pancreatic cancer [ J ]. Clin Cancer Res, 2005 ( 8 ) : 3094 - 3101.
  • 9Kimura A, Martin C, Robinson GW ,et al. The gene encoding the hematopoietic stem cell regulator Ccn3/NOV is under direct cytokine control through the transcription factors STAT5A/B. J Biol Chem, 2010 ;285 (43) :32704 - 32709.
  • 10Zuo GW, Kohls CD, He BC, et al. The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis. Histol Histopathol, 2010; 25 (6) :795 - 806.

引证文献5

二级引证文献12

国际病理科学与临床杂志
2006年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部