摘要
目的:研究半夏泻心汤由传统汤剂改制成胶囊剂的制备工艺条件及急性毒理试验。方法:①制备工艺:采用正交试验法。②急性毒理试验:设5个给药剂量组,组间距为0.75,给药剂量为成人日常常用药量的20倍。一次给药后,观察14d。结果:进行最大耐受量测定。对小鼠的最大耐受量(MTD)为32g/kg,小鼠的最大耐受量倍数为133.33。结论:动物急性试验初步表明:半夏泻心胶囊毒性甚小,临床应用安全可靠。
Objective：To study the preparing condition of the decoction change to the capsul and acute toxinology experiment Methods： orthogonal experiment was used in Artwork. There are five dosages in acute toxinology experiment and group intcrval is 0.75. The dosage is 20 times to adults. The mouse is observed 14 days after dosage. Results： maximum tolerable dose of mouse is 32 g/kg. Times of MTD is 133.33. Conclusion： There is lower toxicity of pinelliae capsul for purging stomach-fire.
出处
《河南中医学院学报》
2006年第5期26-27,共2页
Journal of Henan University of Chinese Medicine
关键词
半夏泻心胶囊
急性毒理试验
LD50
MTD
剂量
Pinelliae capsul for purging stomach-fire
Acute toxinology experiment
LD50
MTD
Dosage
