摘要
目的观察经皮冠状动脉支架置入术(CS)后血浆P-选择素水平的动态变化,并分析其机制和意义。方法选择2003年9月至2004年9月我院行CS的患者为研究对象(n=30),同时选择一组同期进行冠状动脉造影(CAG)的患者作为对照(n=26),CS组于术前1h及术后1h,4h,24h,48,1周采静脉血;CAG组于术前1h及术后1h,4h,24h采静脉血。采用流式细胞术测定血小板表面-选择素的表达。结果CS组患者术后血浆P-选择素水平显著高于术前(P<0·05)。造影前后血浆-选择素水平差异无统计学意义。结论冠状动脉支架置入术后血浆P-选择素水平升高可能是局部急性炎症反应增强的表现。
Objective To study the effect and its mechanism of coronary stenting on blood levels of Pselectin. Methods Thirty patients who received coronary stenting from September 2003 to September 2004 were included in the study and another twenty six patients who received coronary angiography during the same period were selected as controls. Blot samples were drawn at 1 h before and at 1 h, 4 h, 24 h, 48 h, 1 week after coronary stenting. Blot samples were taken at 1 h before and at I h, 4 h, 24 h after coronary angiograpy. Results In patients with coronary stenting, P-selectin levels after the procedure were significantly higher than that before the procedure （P 〈0.05）. However, there was no significant change in plasma P-selectin level before and after coronary angiography. Conclusion Coronary stenting causes a detectable increase in blot levels of P-selectin. It may be a manifestation of the local intrinsic inflammation process or fissure damage after stenting.
出处
《中国介入心脏病学杂志》
2006年第4期226-227,共2页
Chinese Journal of Interventional Cardiology
