摘要
目的探讨缺氧缺血(H I)后C aspase-3的变化及银杏叶提取物(EG b)对新生大鼠缺氧缺血性脑损伤(H IBD)的保护作用。方法夹闭妊娠大鼠子宫血管,制成H IBD新生鼠模型,治疗组给予腹腔注射EG b,比较两组仔鼠脑组织凋亡基因C aspase-3的变化及神经细胞的凋亡情况。结果缺氧缺血后随再灌注时间的延长,脑组织中C aspase-3表达增强,同时凋亡细胞数增加,表明C aspase-3促进凋亡的发生。EG b治疗后C aspase-3表达降低,同时观察到治疗组的凋亡细胞数量减少。结论EG b的抗凋亡机制与抑制C aspase-3凋亡基因的表达有关,EG b对H IBD有脑保护作用。
Objective To assess the expression of Caspase-3 protein in brain after hypoxic ischemic（HI）and investigate the protective effect of extract of ginkgo biloba （EGb）on hypoxic ischemic brain damage （HIBD）in neonatal rats. Methods The HIBD animal models were made by tigating the uterine arteries of pregnant rat. EGb was injected into the HIBD models. The expression of Caspase-3 protein in brain after HI were observed. Results Caspase-3 pretein expression was elevated after HI and reperfusion while apoptosis of cerebral ceils were also elevate. The study showed that the Caspase-3 protein were decreased with the treatment of EGb after HI. EGb decreased the apoptosis of cerebral ceils. Conclusion Caspase-3 may be function as a cell death effector protein. EGb has protective effect on HIBD which minimize the expression of Caspase-3 protein.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2006年第3期336-337,共2页
Journal of Apoplexy and Nervous Diseases
关键词
脑缺血
凋亡
银杏叶提取物
Cerebral ischemia
Apoptosis
Extract of ginkgo biloba
