摘要
随着组织工程和支架材料的技术发展,复合支架材料的制备成为当前研究的热点。本研究通过静电纺丝法制备了左旋聚乳酸/羟基磷灰石(PLLA/HA)复合纳米纤维膜,对纤维膜的结构形态进行分析,并研究其在与人体环境相近的磷酸盐缓冲溶液(pH 7.4,37℃)中浸泡不同时间的体外降解过程。结果表明:HA纳米粒子与PLLA基体间存在化学键合,纳米粒子使纤维直径增大且表面粗糙程度增加,HA的引入抑制了PLLA降解过程中的自催化作用,减缓了PLLA的降解速度,复合纤维体系降解液的pH值在降解后期呈缓慢上升趋势。
The preparation of scaffolds consisted of a polymer composites with inorganic materials has received extensive attention recently in the field of tissue engineering. Electrospinning is a good method to obtain nano-scaled fibers from polymer solutions. In this paper, we successfully prepared non-woven micron-nanofiber mats of poly （l-lactic） （PLLA） and PLLA/hydroxyapatite （HA） by electrospinning. Their structure, morphology and surface degradation behaviors were studied. The results indicated that a strong surface bonding was formed between the two components and the scaffolds had a perfect micro-cellular structure. The surface of hybrid fibers was much coarser because of the introduction of HA nano-particles. The alkaline HA nano-particles inhibited the self-catalysis of PLLA during the degradation and slow down the degradation rates of PLLA fibers. The pH of hybrid system increased slowly after 28days degradation.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2006年第4期476-480,共5页
Chinese Journal of Biomedical Engineering
基金
"863"计划资助项目(2004AA302G50)
国家自然科学基金资助项目(30471907)
关键词
羟基磷灰石
聚乳酸
电纺丝
体外降解
hydroxyapatite（HA）
poly（l-lactic） （PLLA）
electrospinning
in vitro degradation
