摘要
目的：探讨后发性白内障的药物预防。方法：行兔眼白内障囊外摘除术。白内障囊外摘除术为对照组；术中在灌注液中加入三尖杉酯碱（分３种浓度：０．０２５ｍｇ／ｍｌ、０．０５ｍｇ／ｍｌ、０．１ｍｇ／ｍｌ）者为观察组。术后３个月用光镜、扫描电镜和透射电镜观察晶体后囊的形态学变化。结果：术后３个月观察组晶体后囊的透明度优于对照组（Ｐ＜０．０５）。对照组晶体后囊前覆盖一层晶体上皮细胞，并可见Ｂ淋巴细胞和巨噬细胞附着。观察组晶体后囊前无明显晶体上皮细胞增殖和炎性细胞吸附，角膜内皮等眼内组织无明显病理改变。结论：三尖杉酯碱可能为预防后发性白内障较安全、有效的药物。
OBJECTIVES:The study was designed to investigate the preventio n of after-cata-ract with drug.METHODS:Extracapsular cataract extraction was performed on rabbit eye。Extracapsular cataract extraction were performed in control group,and harringtonine solutionswith three different concentration(0.025mg/ml,0.05mg/ml and 0.1mg/ml)were applied in theperforate in drug group,in which the operation olso were performed.Three months later,the path-ological changes of posterior lens capsule were observed by light microscopy,scanning and trans-mission electron microscopy.RESULTS:Three months after the operation,the transparency ofthe lens posterior capsule in the drug group was superior to that in the control group(P<0.05).The lens posterior capsule in the control group was covered by a layer of lens epithelium,and someB-lymphocytes and macrophage attachment could also be observed.In the drug group,obviouslens epithelium muitiplication and inflammatory cellattachment had not been observed on the lensposterior capsule.Pathologic changes in corneal endothelium were not obvious and intraocular tis-sue CONC LUSION:Harringto nine may be a relatiVe ly safe and effective drug on preventingafter-cataract
出处
《中国中医眼科杂志》
1996年第4期195-197,共3页
China Journal of Chinese Ophthalmology
基金
广东省卫生厅资助基金
