摘要
目的：观察长期家庭氧疗对慢性阻塞性肺病患者机体营养状况及细胞免疫功能的影响。方法：36例慢性阻塞性肺病患者，给予家庭氧疗，每日氧流量1～2L／min，平均吸氧（10．4±3．5）h，另设对照组慢性阻塞性肺病患者34例，未予家庭氧疗。18个月后，比较两组经皮氧饱和度、体重指数、肱三头肌皮褶厚度、上臂中点肌肉周径、血浆白蛋白、血浆前白蛋白、血液淋巴细胞计数及细胞免疫功能。结果：治疗后，氧疗组氧饱和度、体重指数、血浆白蛋白、血浆前白蛋白、血液淋巴细胞计数、自然杀伤细胞、CD3^＋、CD4^＋、CD4^＋／CD8^＋较对照组及治疗前均显著增高（P〈0．05）。结论：长期家庭氧疗可显著提高慢性阻塞性肺病患者的营养状况及细胞免疫功能，可能与改善患者的缺氧状况有关。
Objective To observe the effects of cellular immune function and nutritional status in patients with chronic obstructive pulmonary disease treated with long-term domiciliary oxygen therapy. Methods Thirty-six cases of chronic obstructive pulmonary disease were treated with longterm domiciliary oxygen therapy, oxygen flow of 1-2 L/min for average （10.4±3. 5） hours every day. Thirty-four cases of chronic obstructive pulmonary disease in control group did not receive domiciliary oxygen therapy. After 18 months, the indices were compared as SPO2, body mass index, triceps skinfold circumference, blood total lymphocyte count, plasma albumin, plasma pre-albumin, cellular immune function between two groups. Results After 18 months, SPO2, body mass index, plasma albumin, plasma pre-albumin, total lymphocyte count,CD3^＋, CD4^＋, CD4^＋/CD8^＋ and nature killer cell in oxygen group were higher than those before treatment and in control group（P〈0.05）. Conclusion Long-term domiciliary oxygen therapy could prominently improve nutritional status and cellular immune function in the patients with chronic obstructive pulmonary disease. It may be associated with the improvement of patients＇ hypoxia condition.
出处
《实用诊断与治疗杂志》
2006年第9期639-640,共2页
Journal of Practical Diagnosis and Therapy
关键词
慢性阻塞性肺病
长期家庭氧疗
营养不良
细胞免疫功能
Chronic obstructive pulmonary disease
long-term domiciliary oxygen therapy
malnutrition
cellular immune function
