摘要
目的:使用改良质子磁共振波谱技术,观察原发性帕金森病患者黑质内生物化学代谢物改变,并为该技术在帕金森病病理生理研究和临床诊断中的运用提供理论依据。方法:选择2004-01/2005-04在四川大学华西医院门诊和住院部,依据1984年全国锥体外系疾病讨论制定的诊断标准确诊的原发性帕金森病患者29例,作为帕金森病组。同期纳入年龄大于40岁的健康志愿者29名,为正常对照组。均于四川大学华西医院放射科完成黑质磁共振波谱检测。帕金森病组与正常对照组间年龄、性别分布基本一致,除帕金森病外无其他中枢神经系统相关疾病病史。所有受检者在参与实验前均被告知相关事宜并取得受检者同意。采用多体素质子磁共振波谱技术,检测两组脑黑质N-乙酰天门冬氨酸、含胆碱化合物和肌酸浓度水平,比较两组间上述代谢物浓度及N-乙酰天门冬氨酸/含胆碱化合物、N-乙酰天门冬氨酸/肌酸、含胆碱化合物/肌酸比值的差别,并进一步分析其与帕金森病病理及病理生理过程之间相关性。结果:58例实验对象的黑质磁共振波谱信息全部纳入结果分析。原发性帕金森病患者黑质内N-乙酰天门冬氨酸/含胆碱化合物、N-乙酰天门冬氨酸/肌酸、含胆碱化合物/肌酸比值水平与正常对照组之间差异不显著(P>0.05);帕金森病患者黑质内N-乙酰天门冬氨酸和含胆碱化合物水平较正常对照明显降低(P<0.05)。结论:多体素质子磁共振波谱技术能够更准确检测活体内神经生物化学代谢改变,可为帕金森病的临床诊断和病理生理研究提供有利依据。
AIM： To observe the biochemical changes of substantia nigra in patients with Parklnson disease using the improved techniques of proton magnetic resonance, so as to provide theoretic evidence for application in the pathophysiological research on Parkinson disease and clinical diagnosis. METHODS： Twenty-nine primary inpatients and outpatients with Parkinson diseases in the West China Hospital of Sichuan University, diagnosed as primary Parkinson disease according to the diagnosis criteria formulated by National Symposium on Extrapyramidal Disease held in 1984 were selected as Parkinson disease group. Meanwhile, 29 healthy volunteers aged 〉 40 years were enrolled as control group. They received proton magnetic resonance spectroscopy （MRS） detection in Department of Radiology, West China Hospital of Sichuan University. The age, gender distribution of the examinees was basically coincident, and except Parkinson disease, they had no history of other disease of central nervous system. All the participators were informed and agreed to join the test before experiment. Their concentration of the N-Acetyl aspartic acid （NAA）, Choline （Cho） and creatine （Cr） in substantia nigra were detected with the muhi-voxel MRS to find out the difference of them and the values of NAA/Cho, NAA/Cr, Cho/Cr, NAA, Cho/Cr in the two groups. And the relationship between these changes and the pathophysiological progress of Parkinson disease were analyzed. RESULTS： All the 58 persons received the MRS scan were involved in the result analysis. No obvious difference was found in the values of NAA/ Cho, NAA/Cr and Cho/Cr between the two groups （P 〉 0.05）. But the concentrations of the NAA and Cho of the patients with Parkinson disease were lower compared with the healthy people （P 〈 0.05）. CONCLUSION： The muhi-voxal proton magnetic resonance spectroscopy scan can better detect the metabolic changes of the central neural system in living persons and the results of the test can help the diagnosis and researches of the pathophysiologial progress of Parkinson disease.
出处
《中国临床康复》
CSCD
北大核心
2006年第34期112-114,F0003,共4页
Chinese Journal of Clinical Rehabilitation
