摘要
为探讨甲状腺髓样癌的多分化，用免疫组织化学方法对２４例甲状腺髓样癌进行研究。结果显示：癌组织中见甲状腺球蛋白阳性细胞３例、降钙素阳性细胞２４例、铬粒素Ａ阳性细胞２３例、５－羟色胺阳性细胞１４例、神经元特异性烯醇化酶和生长抑素阳性细胞均为１０例、血管活性肠肽阳性细胞４例、Ｓ－１００蛋白阳性细胞１例。本组癌的多种抗原表达提示，它可能来源于可以产生多种激素的神经外胚叶细胞。另有３例见甲状腺球蛋白阳性癌细胞，提示：甲状腺髓样癌伴滤泡上皮分化和混合性髓样癌并不少见，可能来源于能向两个方向分化为滤泡上皮细胞和滤泡旁细胞的后腮干细胞。
Inordertostudythemultidiferentiationofmedularycarcinomaofthethyroidgland(MCT),24casesofMCTwereexaminedforthepresenceofimmunoreactivecalcitonin(CT),thyroglobulin(Tg),chromograninA(CgA),somatostatin(SS),serotonin(5-HT),S-100protein(S-100),neuron-specificenolase(NSE),vasoactiveintestinalpolypeptide(VIP),adrenocorticotrophin(ACTH)andneurofilamentprotein(NF)byusingimmunohistochemicalABCmethods.ResultsshowedthatCT-immunoreactivecelswerepresentinaltumors.Tgwaspresentinthreetumors.23casescontainedCgA-immunoreactivecels.14tumorscontained5-HT-immunoreactivecels,10caseswereimmunoreac-tivetoNSEandSS.4tumorscontainedVIP-immunoreativecelsandonlyonecaseswaspositiveforS-100.Thedemonstrationofimmunoreactivityformultipleantigensin24casessuggeststhattheoriginofmedularythyroidcarcinomamayoriginatefromneuroectodermcelspotentialycapableofproducingnumeroushormonesubstances.Inaddition,astheneoplasticcelsin12%ofthetumorscontaininghor-monesubstancesaswelasthyroglobulin,itissuggestedthatfolicularepithelialdifferentiationandmixedmedularythyroidcarcinomamaybemorecommonthanpreviouslysuspected.Recentstudiesin-dicatethatmixedcarcinomaofthethyroidmaybederivedfromcommonstemcelsinposteriorbranchiacapableofdiferentiatingintobothfolicularandparafoliculartumorcels.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1996年第6期332-335,共4页
Chinese Journal of Pathology
