摘要
本文应用铬粒素Ａ（ＣｇＡ）、胃泌素（ＧＡＳ）、生长抑素（ＳＳ）及５－羟色胺（５－ＨＴ）对１２０例普通型胃癌用免疫组化ＳＰ法标记其神经内分泌细胞。结果表明：四种激素抗体检测，以ＣｇＡ最敏感、阳性率最高为３１．７％；高分化腺癌ＣｇＡ阳性率显著高于低分化和未分化癌（Ｐ＜０．０５），但高分化腺癌ＣｇＡ阳性病例以（＋）为主，未分化癌以（＋＋）为主；而ＳＳ．５ＨＴ的阳性率，高、低分化腺癌均高于未分化癌（Ｐ＞０．０５）。ＣｇＡ及５－ＨＴ阳性病例淋巴结转移率高于阴性病例（Ｐ＜０．０５），ＣｇＡ（＋＋）病例术后生存期明显短于ＣｇＡ（＋）及ＣｇＡ（－）者（Ｐ＜０．０５），ＧＡＳ、５－ＨＴ及ＳＳ阳性与阴性病例术后生存期无显著差异。
One hundred and twenty cases of gastric carcinomec were examined with immunohistochemical SP method for chromogranin A (CgA), gastrin (GAS), somatostain (SS) and serotonin (5-HT) follows: Among four antibodies, CgA was most specific, 31. 7% gastric carcinoma had CgA-positive cells; the positive rate of CgA in the well differentiated carcinomas was higher than that of the poorly differentiated ones and undifferentiated carcinomas (P<0. 05), CgA-positive undifferentiated carcinomas had more NE cells(+ + ); but among different histological type,the positive rate of 5-HT and SS in undifferentiated carcinomas was lower (P>0.05). CgA and 5-HT positive cases had higher lymph node metastasis rate than the negative ones (P<0. 05). The cases with CgA-positive cells (+ + ) exhibited shorter survival time than those with few CgA-positive cells(+ ) and without CgApositive cells (P<0. 05), after having analysed the survival time, we found there was no significant difference between GAS, b-HT, SS positive and negative cases.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1996年第6期347-349,共3页
Cancer Research on Prevention and Treatment
关键词
胃癌
神经
内分泌
免疫组化
病理学
gastric carcinoma
neuroendocrine cells
immunohistochemistry
