摘要
目的探讨D-二聚体(D-dimer,DD)在排除肺栓塞诊断中的临床价值。方法使用ELISA法对可疑肺栓塞患者血浆中纤维蛋白降解产物DD进行检测,并对这些可疑肺栓塞患者进行半年的随访,了解是否有肺栓塞或深静脉栓塞的症状。结果共有102例患者参加检测,42例患者(41.1%)的DD检测值<500μg/L,60例患者血浆中的DD检测值>500μg/L,其中有11例患者通过肺通气灌注扫描(V/Q)证实为肺栓塞。ELISADD法的敏感性为100%,阴性预期值为100%。结论DD检测方法简便易行,设备要求不高,可作为排除肺栓塞的首选试验,易在临床诊断中推广使用。
Objective The aim of this study is to evaluate the value of the plasma D-dimer detection in the diagnosis of excluding pulmonary embolism. Methods D-dimer levels were determined by enzyme-linked immunoabsorbent assay （ELISA） in patient with suspicion of pulmonary embolism,and carries on for half year to those patients to make a follow-up visit to see whether they have the symptom of pulmonary embolism or deep phlebothrombosis. Results Of all the 102 patients included, were detected,D-dimer levels were below 500 μg/L in 42 （41.1% ）patients, D-dimer levels were above 500 μg/L in 60 patiems, 12 of them were proved were diagnosis of pulmonary embolis by pulmonary angiography V/Q. Lung scan Sensitivity and negative predictive values of D-dimer detection were 100%. Conclusion D-dimer detec detection is easy to work out and do not need complex equipment,it could be the first test of excluding pulmonary embolism, and is easyto spread in clinical diagnose.
出处
《实用医技杂志》
2006年第16期2779-2781,共3页
Journal of Practical Medical Techniques
关键词
肺栓塞
D-二聚体
酶联免疫吸附反应
Pulmonary embolism D-dimer
Enzyme linked immunoabsorbent assay
