摘要
观察了ＮＰＣ患者和不同滴度ＩｇＡ／ＶＣＡ者的Ｔ淋巴细胞亚群、免疫球蛋白（ＩｇＧ、ＩｇＡ、ＩｇＭ）和补体Ｃ３的变化。结果提示，鼻咽癌患者的Ｔ细胞亚群失调，细胞免疫功能明显降低而体液免疫功能明显增高；ＮＰＣ患病风险者──高滴度ＩｇＡ／ＶＣＡ者的免疫功能发生了与ＮＰＣ患者相似的变化；低滴度ＩｇＡ／ＶＣＡ者的细胞免疫功能也开始趋向于抑制状态。研究结果为ＮＰＣ发病的免疫机制和防治提供了重要的实验依据。
T lymphocyte subsets,immunoglobulin(IgG,IgA,IgM)and C3 of nasopharyngeal carcinoma(NPC)patients and individuals with varied titer of IgA/VCA were observed in this article. The results showed that from NPC patients,CD3,CD4 cells and ratio of CD4/CD8 were obviously lower but CD3 cells and lgG,IgA were obviously higher than other groups;that from NPC risker-individuals with high titer of IgA/VCA changed between NPC patients and individuals with low titer of IgA/VCA;CD3 from individuals with low titer of IgA/VCA was higher than IgA/VCA negativeness.This suggested that T cell subsets are imbalanced,cellular immunity is significantly lowered and humoral immunity is significantly increased in NPC patients. The cellular immunity in individuals with high titer of IgA/VCA has a similar change as that in NPC patients and tend to inhibiting state in individuals with low titer of IgA/VCA,The results would provide an important experimental basis for immune pathogenesis and prevention and cure of NPC.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1996年第6期370-373,共4页
Chinese Journal of Immunology
基金
全军医药卫生科研基金
关键词
鼻咽肿瘤
T细胞亚群
免疫球蛋白
EB病毒
Nasopharyngeal carcinoma T cell subset Immunoglobulin Ep stein-Barr virus IgA/VCA
