摘要
目的探讨人胃腺癌发展过程中热休克蛋白70(HSP70)的表达与病理分型、浸润深度和淋巴结转移的关系。方法应用免疫组织化学S-P法检测52例人胃腺癌组织中HSP70的表达。结果胃腺癌和黏液腺癌的HSP70阳性率分别为64.29%和60.00%;高分化和低分化腺癌的HSP70阳性率分别为67.86%和50.00%;胃腺癌HSP70的阳性率在不同病理分型、不同分化程度的肿瘤之间差别均无显著意义。侵犯深度达浆膜和肌层的胃腺癌HSP70阳性率分别为75.68%和33.33%(P<0.05)。有淋巴结转移和无淋巴结转移组中HSP70阳性率分别为73.33%和45.45%(P<0.05)。结论人胃腺癌HSP70中阳性率与淋巴结转移、侵犯深度有关,与病理分型无关。提示胃腺癌晚期HSP70的表达高于早期胃腺癌,检测该指标可为早期诊断胃腺癌提供理论依据。
Objective To explore the relationship between the expression of HSP70 and tissue type, invasive depth and lymphatic rode metastasis in human gastric cancer tissues. Methods The expressions of HSP70 in human gastric carciaoma tissues were detected by immuuohistoehemical staining. Results （ 1 ） The positive ratio ef HSP70 in gastric adenocarcinoma and mueinous adenocarcinoma were 64. 29% and 600% respectively. The positive ratio of HSP70 in high-differentiated and low-differentiated gastric adenocarcinoma was 67.86% and 50.00% respectively. There was no significant difference in the positive ratio of HSP70 between different pathological type and various differentiated carcinoma tissues （P 〉 0.05 ）. （2） The pesitive ratio of HSP70 in invasive to chorion and to muscular layer was75.68% and 33.33% with significant difference （P 〈0.05）. （3） The positive ratio of HSP70 in lymphatic node metastasis and non-lymphatic node metastasis were 73.33% and 45.45% with significant difference （ P 〈 0.05 ）.Conclusions The expression of HSP70 has relationship with lymphatic node metastasis and invasive depth and has no relationship with differentiated degree, which indicates that the expression ratio of HSP70 in advanced gastric adenoearcinoma could he higher than that in early gastric adenocareinoma. The detection of HSP70 can provide theoretical basis for diagnosing gastric adenocarcinoma earlier.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2006年第2期166-167,共2页
Chinese Journal of Gerontology
基金
河北省科技厅攻关项目(No3276117)
关键词
胃腺癌
热休克蛋白70
免疫组织化学
Gastric adenocarcinoma
Heat shock protein 70
Immunohistochemistry
