摘要
HFRS病毒陈茱、76-118株和R22株100LD_(50)分别感染新生乳鼠。感染后24h,经腹腔分别接种McAb(3D8、3G1、8F8、8G3和8G2)和免疫血清(陈株、76-118株和R22株),结果发现,这5株McAb对陈林和76-118株感染乳鼠100％保护,而对R22株感染乳鼠只有McAb8F8有25％保护,而其佘McAb均无保护。免疫血清的保护实验也表明,陈株和76-118株可以交互保护。上述结果提示,陈株与76-118株保护性抗原较一致,但R22株与前两株差别较大。
The five McAbs (3D8, 3G1, 8F8, 8G3 and 8G2 ) protected respectively suckling mice infected 100 LD50 HFRS virus strains Chen, 76-118 and R22. The three strain virus immuued sera were done also. The five McAbs protected 100% suckling mice from Chen and 76-118 strain virus lethal infection But only 8Fs protected 25% suckling mice from R22 strain virus lethal infection, the other four McAbs had no protection.The result of three virus strain immued mice serum protection had the same conclusion strain Chen and 76-118 virus protective antigen have little difference. Strain R22 virus had more difference from strain Chen and strain 76-118 virus. The three HFRS virus strains had common protective antigen determinant sit.
