摘要
用复方黄芪治疗慢性迁延性肝炎８７例和慢性活动性肝炎２９例，临床显效率分别为６９．０％和５５．２％，总有效率分别为９０．８％和８９．７％；血清ＨＢｅＡｇ和ＨＢＶ－ＤＮＡ阴转率分别为２７．７％和２８．０％，均显著高于对照组（Ｐ＜０．０５～０．０１）。治疗鸭乙型肝炎模型８只，血清ＤＨＢＶ－ＤＮＡ阴转３只，ＤＨＢＶ－ＤＮＡ平均水平治后比治前明显下降（Ｐ＜０．０５）；鸭肝组织呈轻度炎症改变者３只，病变比对照组轻，原位杂交ＤＨＢＶ－ＤＮＡ定位２只鸭阴性。结果显示，复方黄芪具有较好保肝和一定的抑制ＨＢＶ复制作用。
Eighty-seven cases of chronic persistent hepatitis(CPH) and 29 cases of chronic active hepatitis(CAH) were treated with Astragali Composita(AC),the clinical markedly effective rates were 69.0% and 55.2%,the total effective rates were 90.8% and 89.7% respectively,the sero-negative conversion rates of HBeAg and HBV-DNA were 27.7% and 28.0% respectively,they were higher than that of control group(P<0.05￣0.01).Eight ducks infected duck hepatitis B virus were treated with AC,sero-negative conversion of DHBV-DNA was seen in 3 ducks,DHBV-DNA levels of duck sera were lower after treatment than that before treatment(P<0.05);mild inflammatory changes in liver tissues were seen in 3 ducks,its pathologic changes were milder than that of control groups;DHBV-DNA in liver tissues of 2 ducks was negative in situhybridization.The results indicated that AC had obvious effects of protecting liver tissues and some effects of inhibiting sera HBV and HBV replication.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1996年第7期394-397,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
浙江省中医管理局
浙江省教委资助
关键词
复方黄芪
慢性
乙型肝炎
中医药疗法
Astragali Composita,chronic hepatitis B,duck hepatitis B model
