摘要
目的:探讨中药制剂蝙蝠葛酚性碱片的溶出度,为临床用药提供参考。方法:采用紫外分光光度法,分别对其溶出介质、转速进行考察,对累积溶出百分率进行测定,并对3批样品进行均一性试验。结果:蝙蝠葛酚性碱片在45 m in内即溶出70%以上,相对标准偏差在3.0%以内。结论:中药固体制剂蝙蝠葛酚性碱片按照《中国药典》(二部)有关溶出度测定方法控制其内在质量是可行的,可保证临床用药安全、有效。
Objective： To investigate the dissolution of phenolic alkaloids of menispermum dauricum tablet （ PAMDT）, and supply some information for clinical medication. Method： To used the ultraviolet spectrophotometry and detect the dissolved medium and rotation speed, to determine accumulative dissolution percentage and do homogenicity test to three batches samples. Result： the PAMDT dissolved more than 70% in 45 minutes, the RSD is lower than 3%. Conclusion： the method to control the quality of PAMDT is feasible according to the assay method of dissolution of Pharmacopeia of China, can ensure safety and good for clinical medication.
出处
《中医药导报》
2006年第8期92-93,共2页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
