摘要
目的研究动脉瘤性蛛网膜下腔出血(SAH)患者血清可溶性黏附分子1(sCAM1)的动态变化规律。方法用酶联免疫吸附法(ELISA)对30例动脉瘤性SAH患者术前、术后1～3d、7～9d、11～13d血清sCAM1进行动态观察,用经颅多普勒检测大脑中动脉血流速度(VMCA),并与20名健康对照者进行比较。结果动脉瘤性SAH患者血清sCAM在术后1～3d、7～9d各均值明显高于正常对照组(均P<0.05),尤以术后7～9d最明显;Fiaher、Hunt不同分级患者血中CAM1浓度以出血量大、病情重升高明显(P<0.05,P<0.01);脑血管痉挛(CVS)程度重者sCAM1浓度升高明显(P<0.05);术前、术后CVS组和非CVS组差异有显著性(均P<0.05)。结论动脉瘤性SAH患者血清sCAM含量与病程、病情及CVS程度有关。
Objective To study the dynamic changes of serum concentration of soluble cell adhesion molecule （sCAM） in patients with aneurysmal subarachnoid hemorrhage. Methods Serum concentrations of sCAM in 30 patients with aneurysmal subarachnoid hemorrhage were detected using ELISA method before surgery and at 1 -3 d, 7-9 d and 11 - 13 d after surgery. Transcranial Doppler sonography was used to measure the velocity of middle cerebral artery （VMCA）. The results were compared with 20 healthy controls. Results Serum concentrations of sCAM at 1 - 3 d and 7 - 9 d in patient group were significantly higher than that in control group （ all P 〈 0. 05 ）. The serum concentrations of sCAM were also higher in the patients with larger volume of bleeding or severe clinic conditions according to Fiaher or Hunt grading （ P 〈0. 05, P 〈0. O1 ） and in the patients with severe vasospasm （ P 〈0. 05 ）. There were significant differences of serum concentrations of sCAM between the patients with cerebral vasospasm （CVS） and the patients without CVS before and after surgery. Conclusion The serum concentration of sCAM in patients with aneurysmal subarachnoid hemorrhage is related to the course of disease, patient＇s condition and cerebral vasospasm.
出处
《临床神经病学杂志》
CAS
北大核心
2006年第4期278-280,共3页
Journal of Clinical Neurology
基金
江苏省135工程资助课题(编号:36RC2002036)
