摘要
心房颤动(atria l fibrillation,AF)是最常见的心律失常,在二尖瓣病变患者中发病率高达79%。AF容易引起血栓、栓塞和严重心律失常。药物转复窦性心律仍有易复发的倾向,而外科手术和射频消融仅能使部分患者受益。迄今为止,AF的发病机制仍不清楚。现通过致病基因、心肌电生理、连接蛋白、细胞超微结构和细胞信号传导系统等五个方面对AF的病因和发病机制进行综述。
Atrial fibrillation （AF） as a most frequent arrhythmia has a high incidence of 79% in patients with mitral valve disease. Thrombosis, embolization and serious arrhythmia can be caused by AF. There is the recrudescent tendency in using drugs to recover the sinus rhythm, surgery and radio frequency ablation can only cure a part of patients. By now the pathogenesis of AF is not known clearly. The pathogenesis of AF from virulence gene, cardiac electrophysiology, connecxins, cell ultramicrostructure and cell signaling system are reviewed in this article.
出处
《中国胸心血管外科临床杂志》
CAS
2006年第4期264-267,共4页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
心房颤动
病因学
心律失常
Atrial fibrillation
Etiology
Arrhythmia
