摘要
目的检测病毒性肺炎患儿的免疫指标(T细胞亚群、免疫球蛋白),探讨病毒性肺炎患儿免疫功能的变化。方法将血清病毒特异性IgM抗体阳性,CRP<8mg/L且无其他病原感染的病毒性肺炎患儿分为1个月￣3个月、￣1岁、￣3岁三个组和相应的对照组。T细胞亚群采用碱性磷酸酶标记链霉卵白素(SAP)法;免疫球蛋白用散射比浊法。统计分析检验结果。结果T细胞亚群CD3、CD4降低,CD8增高,CD4/CD8比值减小,与对照组比较(P<0.05)差异有显著性;血清免疫球蛋白(IgG、IgA、IgM)与对照组比较(P>0.05)差异无显著性。结论婴幼儿病毒性肺炎体液免疫无明显改变,细胞免疫功能受到明显抑制。
[Objective] To explore immunological changes of infant with viral pneumonia, detecting the T Lymphocyte subpopulation and immunoglobulin in their blood. [Methods] The viral pneumonia infant were divided into four groups 1-3 months old, -1 years old, -3 years old and control. On the condition that serum virus specific-IgM was positive and CRP〈8 mg/L and there were no clinical or laboratory proof of other pathogeny infection. T Lymphocyte subpopulation was detected by Streptavidin-alkaline phosphatase （SAP） method. Immunoglobulin and C-reacfive protein were detected by rate scattered nephelometry with specific protein analyzing instrument. The results were analysed with statistical T test. [Results] T lymphocyte subpopulation CD3, CD4 falls, CD8 rise, CD4/CD8 rate diminishs, there were obvious difference by comparison with control group （P 〈0.05）. Serum immunoglobulin （IgG, IgA and IgM） have no obvious difference by comparison with control group （P 〉0.05）. [Conclusion] Function of the body immune system of infant viral pneumonia has no obvious change. But then function of the cell immune system change is obvious.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第15期2346-2347,共2页
China Journal of Modern Medicine
