摘要
目的:观察妊娠高血压综合征(妊高征)患者胎盘床螺旋动脉血管内皮素(ET-1)的表达情况,探讨妊高征的发病机理。方法:收集正常妊娠病例30例、妊高征70例(其中轻度30例,中度20例,重度20例),采用免疫组织化学方法观察妊高征和正常妊娠胎盘床蜕膜段和肌层螺旋动脉ET-1的表达情况。结果:ET-1在妊高征胎盘床蜕膜段螺旋动脉内皮细胞的表达与正常妊娠无明显差别(P>0．05),ET-1在妊高征胎盘床肌层螺旋动脉内皮细胞的表达明显高于正常妊娠(P<0．05)。结论:妊高征时肌层螺旋动脉内皮细胞分泌内皮素明显增多,提示妊高征的发生可能与内皮素的分泌增多有关。
Objective：To observe the expression of ET-1 in placental bed spiral artery of edema-hypertension-proteinuria syndrome patients, and to explore the pathogenesis of edema-hypertension-proteinuria syndrome. Methods： 30 cases of normal pregnancy and 70 cases （among them： 30 cases mild, 20 cases midrange and 20 cases severe ） of edema-hypertension-proteinuria syndrome were investigated. Immunohistochemical technique was used to observe the ET-1 expression in desidual-spiral artery and myo-spiral artery of placental bed. Results： The expression of ET-1 in decidual-spiral artery had no significant differenee between normal pregnancy and edema-hypertension-proteinuria syndrome （P〉 0. 05）. While the expression of ET-1 in myo-spiral artery of edema-hypertension-proteinuria syndrome was obviously higher than normal pregnancy （P〈0. 05）. Conclusions： In edema-hypertension-protcinuria syndrome, the secretion of ET-1 in myo-spiral artery increased significantly, which indicate that the increasing of ET-1 might play an important role in the development of edema-hypertension-proteinuria syndrome.
出处
《承德医学院学报》
2006年第3期235-237,共3页
Journal of Chengde Medical University
关键词
妊娠高血压综合征
胎盘床
螺旋动脉
ET-1
Edema-hypertension-proteinuria syndrome
Placental bed
Spiral artery
ET-1
