摘要
目的探讨血小板生成素(TPO)和巨核细胞计数对特发性血小板减少性紫癜(ITP)患儿预后的意义。方法采用夹心酶联免疫吸附法测定122例ITP患儿血清TPO水平,根据巨核细胞数分为A组(巨核细胞数≤35/6 cm2)与B组(巨核细胞数>35/6 cm2),两组进行TPO水平比较,并观察各组疗效。结果A和B组TPO水平分别为(368.33±39.47)ng/L,(141.48±11.28)ng/L。A组明显高于B组,有显著性差异(t=7.44 P<0.01)。A组治疗有效率为23.8%,明显低于B组84.2%,其差异有显著性(χ2=6.54 P<0.05)。A组有效5例TPO为(109.60±15.59)ng/L,无效16例TPO为(449.18±29.59)ng/L,其差异有显著意义(t=-6.23 P<0.01)。结论ITP患儿血清TPO水平存在较大差异,TPO水平明显增高且无巨核细胞数增高者疗效差,可能提示预后不良。
Objective To explore the prognosis of idiopathic thrombocytopenic purpura（ITP） in serum levels of thrombopoietin （TPO） and number of megakaryocyte. Methods Serum levels of TPO were measured with sandwich-enzyme linked immunosorbent assay kit. According to the number of megakaryocyte, the patients were divided into group A （the number of megakaryocyte was less than or equal to 35/6 cm^2 ） and group B（the number of megakaryocyte is higher than 35/6 cm^2） and reviewed their curative effects. Results The mean serum level of TPO in group A was （368.33±39.47） ng/L and that in group B was （ 141.48±11.28） ng/L. The serum levels of TPO in group A were visibly higher than those in group B. There was statistical difference between group A and group B（ t=7.44 P〈0.01 ）. The therapeutic effective power in group A was 23.8 % and remarkably decreased than 84.2 % in group B（X^2 = 6.54 P 〈0 .05 ）. The mean serum TPO levels in 5 responders in group A [ （ 109.60±15.59） ng/L ] was significantly lower than that in 16 nonresponder in group A[ （449.18±29. 59） ng/L] intreatment（t= -6.23 P〈0.01）.Condusions There is markedly difference in serum level of TPO in children with ITP. The high level of TPO and lower number of megakaryocyte prognosticated infaust prognosis in ITP.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第15期987-988,共2页
Journal of Applied Clinical Pediatrics
