摘要
目的探讨2型糖尿病患者的大脑功能状态及认知障碍的可能机制。方法对2型糖尿病患者及健康对照组进行心理学检查及磁共振波谱、功能磁共振成像(MR)检查。结果2型糖尿病患者的记忆功能总体下降,记忆商显著降低[糖尿病组(94．95±13．82)分,对照组(118．50±17．30)分,P＜0．01],手眼协调能力降低,焦虑抑郁程度较高(P＜0．05),糖尿病组fMRI成像反应时长[(1029．00±105．55)ms,(886．35±82．40)ms,P＜0．01]、正确率低于对照组,2back减去0back任务时双侧额叶、顶叶及底节小脑激活强度明显减低。结论2型糖尿病人认知功能的降低与fMRI检查结果相一致。
Objective To study the brain functional status of type 2 diabetes, and discuss the possible mechanism of cognitive dysfunction in type 2 diabetes. Methods Psychologic test and the brain functional test （fMRI and MRS）type 2 diabetes group（ n =20） and control group（ n = 15） , then compared the results of two groups. Results Compared with the control group, there were the debasing of totally memory （94.95 ± 13.82 vs 118.50± 17.30, P〈 0. 001 ） and the harmony between hands and eyes in type 2 diabetes group. And they have the higher level of anxiety and depression（ P〈0.05 ）. For fMRI, there are the longer reaction time （ 1029. 00 ± 105.55,886.35 ± 82.40, P 〈 0.001 ） and less correctness in type 2 diabetes group. And their activation intensity of both side frontal lobe.parietal lobe and basal ganglia were significantly decreased when 2back task minus 0back task. Conclusion The debasing of cognitive function accord with the result of MR test. Possibly pathologic basis induce the anxiety and depression of diabete patients.
出处
《中国行为医学科学》
CSCD
2006年第8期695-697,共3页
Chinese Journal of Behavioral Medical Science
关键词
2型糖尿病
记忆功能
功能磁共振成像
Type 2 diabetes
Memory function
Functional magnetic resonance imaging
