摘要
目的:了解藏边大黄复合剂对糖尿病小鼠血糖的影响。方法:将糖尿病模型动物依据血糖水平随机分为4组,每组15只,剂量分别为0、125 mg/kg、250 mg/kg、750 mg/kg组,即1个模型对照组(蒸馏水)和低、中、高3个实验组。经口连续给予受试物30 d后取尾血测定空腹血糖值和给葡萄糖后0、0.5、2 h的血糖值,观察给葡萄糖后各时间点血糖曲线下面积的变化。结果:750 mg/kg剂量组能降低高血糖模型小鼠空腹血糖,与模型对照组比较差异有显著性(P<0.05),250 mg/kg、750 mg/kg剂量组能减少高血糖模型小鼠血糖曲线下面积,与模型对照组比较差异有显著性(P<0.05)。结论:藏边大黄复合剂对高血糖模型小鼠空腹血糖有明显降低血糖的效果,并能提高高血糖模型小鼠对葡萄糖的糖耐量。
Objective： To observe the therapeutic effect of Tibet＇s rhubarb compound （TRC） on diabetic mice induced by injecting aUoxan. Methods： Diabetic model of mice were divided into 4 groups according to their blood glucose. Four groups were orally administrated with TRC 0, 125, 250, 750 mg/kg for 30 days, respectively. At the end of trial, blood- glucoses were measured at 0 h, 0.5 h, 2 h after glucose administrated with the dosage of 2 g/kg BW （blood glucose value at 0 h was equal to empty stomach）. Glucose tolerance （GT） was indicated by area under the curve of blccd glucose （ACBG）. Results： Blood glucoses in 750 mg/kg group were significantly decreased compare to control group at 0 h （P〈0.05）. The ACBGs in the 250 mg/kg and the 750 mg/kg groups were significantly lower than control group （P〈0.05）. Conclusion： TRC had effects of decredsing blood gluoose and improving GT in diabetic model of mice induced by alloxan.
出处
《现代预防医学》
CAS
北大核心
2006年第8期1344-1345,共2页
Modern Preventive Medicine
关键词
藏边大黄
三七
高血糖模型
Tibet＇s rhubarb
Panax pseudo- ginseng
Diabetes
