摘要
采用ＨＰＬＣ法对原材料ＥＤＦＭＰ、非放射性Ｓｍ－ＥＵＴＭＰ和１５３Ｓｍ－ＥＤＴＭＰ进行分析。结果表明：原材料没有其它有机杂质；天然钐靶堆照后的放射性核纯度为９９．７％；１５３Ｓｍ－ＥＤＴＭＰ的放射性浓度＜１．８５ＧＢｑ／ｍｌ时，自辐射分解不会影响使用。对标记率采用不同分析方法进行对比表明，快速柱色层分析方法一般仅需５—１０ｍｉｎ即可准确测得标记率或放射化学纯度。比原来纸层析法（需２—３ｈ）简捷快速。小鼠的组织分布实验中，天然靶制备的１５３Ｓｍ－ＥＤＴＭＰ的分布结果与富集靶的没有明显差异。实验结果表明，天然丰度靶经照射后制备１５３Ｓｍ－ＥＤＴＭＰ完全可以满足临床要求。
The HPLC analysis shows that Sm-EDTMP and 153Sm-EDTMP contain no organic impurity. Theradionuclide purity of 153Sm is about 99. 7%. Autoradiolysis will make no contribution when the solution of 153Sm-EDTMP is with a radioactive concentration of less than 1. 85 GBq/ml. For the short halflife of 153Sm, the column chromatographic method needs only 5-10 min for radiochemical purity analysis, while the paper chromatography needs 2-3 h. Animal tests show that there is no obvious difference between the biodistribution results in rats for the natural target prepared 153Sm-EDTMP and the enriched Sm2O3 prefered 153Sm-EDTMP.
出处
《同位素》
CAS
北大核心
1996年第3期154-159,共6页
Journal of Isotopes
