摘要
应用免疫组化检测慢性乙型肝炎４０例的肝组织细胞间粘附分子－１（ＩＣＡＭ－１）。以正常肝６例对照，肝炎３７例的肝细胞膜ＩＣＡＭ－１表达阳性，对照组则阴性。ＩＣＡＭ－１在肝细胞膜的表达与肝脏炎症分度和血清ＡＬＴ水平密切相关，提示乙型肝炎时ＩＣＡＭ－１在细胞毒Ｔ细胞对肝细胞的损伤中起重要作用，ＩＣＡＭ－１肝细胞的表达程度与病毒复制标志物无相关性。提示ＨＢＶ不直接启动ＩＣＡＭ－１在肝脏的表达。
The expression of ICAM 1 was studied by in situ immunohistochemistry in 40 liver biopsy specimens with chronic hepatitis B (CHB) by immunohistochemistry method,and 6 normal livers were used as control.ICAM 1 was expressed on hepatocyte membrane in 37 cases.The degree of ICAM 1 expression was closely related to the histological activity grade and the ALT level.These results suggest that ICAM 1 may play an important role in the pathogenesis of hepatocellular injury mediated by cytotoxic T cell in CHB.No correlation was found between the degree of hepatocyte ICAM 1 expression and viral replication markers (the presence of HBcAg in liver and the HBeAg in serum) in patients with CHB.These results showed that the ICAM 1 expression in liver was not directly enhanced by hepatitis B virus itself.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1996年第4期254-256,共3页
Medical Journal of Chinese People's Liberation Army
关键词
细胞间粘附分子
乙型肝炎
免疫组织化学
intercellular adhesion molecule 1
chronic hepatitis B
immunohistochemistry
