摘要
目的探讨新生儿溶血病(HDN)血清学检验及葡萄糖6磷酸脱氢酶(G6PD)定量测定在病理性黄疸患儿病因诊断中的意义。方法按检验操作规程对出生后1周内发生病理性黄疸的患儿进行HDN血清学检验和G6PD定量测定。结果(1)在416例黄疸患儿中,母子ABO血型不合的HDN有108例(25·96%)。其中,母/子血型为O/A(B)组合的患儿HDN发生率极显著高于母/子血型为A(B)/B(A)组合的患儿(P<0·01)。(2)在416例黄疸患儿中,母子Rh血型不合的HDN仅有1例(0·24%)。(3)在416例黄疸患儿中,G6PD缺乏的有80例(19·23%)。其中,G6PD缺乏的男性患儿极显著多于女性患儿(P<0·01)。结论HDN和G6PD缺乏是本地区新生儿发生病理性黄疸主要的病因;对黄疸患儿及时进行HDN血清学检验及G6PD定量测定,对选择治疗方案有重要的意义。
Objective To discuss the significance of the G6PD-mensuration and the HDN serology verification in the pathogenic diagnosis of the neonates with pathological jaundice. Methods According to the manipulation regulation,the serology of HDN and the G6PD in the neonates those who developed pathological jaundice in a week after birth were examined. Results （1）Of 416 cases with pathological jaundice, 108 （25.96 % ） cases whose ABO-blood-type didn＇ t match their mothers＇ developed HDN. The morbidity of HDN was remarkable higher in the mother-baby blood type combination O/A（B） comparing with the combination A（B）/B（A） （P 〈 0.01 ）. （2）Of 416 cases,only 1 （0.24%） developed HDN in the unmatchable mother-baby＇s Rh-blood-type. （3）Of 416 cases, 80 （19.23 % ） cases were in.the state of G6PD deficiency. And in the G6PD deficiency patient-infants, the male was more remarkable than the female（P〈 0.01 ）. Conclusion In local neonates,HDN and G6PD deficiency are the primary causes of pathological jaundice. It has a great significance for choosing an Rx well and truly by verifying the serology of HDN and mensurating the G6PD in time.
出处
《中国基层医药》
CAS
2006年第7期1089-1090,共2页
Chinese Journal of Primary Medicine and Pharmacy
