摘要
目的探讨黄芪注射液治疗银屑病的机制。方法取患者静脉血分离淋巴细胞培养,设为空白对照组(等量培养液);低浓度(125μg/ml)、中浓度(250μg/ml)、高浓度(500μg/ml)黄芪组;分离正常人淋巴细胞作为正常对照组,应用流式细胞仪测定不同浓度黄芪干预下外周血淋巴细胞CD4/CD8的表达。结果空白对照组与正常对照组相比,空白对照组CD4/CD8比值下降,差异有统计学意义。处理组间的SNK多重比较,得出空白对照组与低浓度组差异无统计学意义,与中、高浓度组差异均有统计学意义(P<0.05),但中、高浓度组差异无统计学意义。结论黄芪注射液对外周血淋巴细胞CD4/CD8比值有明显调节作用。黄芪注射液对CD4/CD8比值的影响可能是其治疗银屑病的机制之一。
Objective To study the mechanism of Astragnlus injection on treating psoriasis. Methods Peripheral blood mononuelear cells from Psoriasis and normal control were cultured and stimulated with different concentration Astragulus injection. The expression of CD4/CD8 ratio were measured with flow eyometry. Results The levels of CD4/CD8 ratio in patient is significantly lower （P〈0.05）than that of normal controls. Low concentration Astragulus Injection do not influence expression of CD4/CD8 ratio. High concentration Astragulus elevated the expression of CD4/CD8 ratio. Conclusion The results suggest that effects of Astragulus Injection on CD4/CD8 ratio of lymphoeytes in oatients with Psoriasis might play an important role in the treatment of the psoiasis.
出处
《中国药物与临床》
CAS
2006年第7期505-506,共2页
Chinese Remedies & Clinics
基金
山西省青年科技研究基金资助项目(20011030)
