摘要
目的:探讨表浅性血管粘液瘤(SA)的临床病理、免疫组织化学特点及生物学行为。方法:对3例表浅性血管粘液瘤进行临床病理学观查,并对三例标本石蜡切片行Vimentin、CD34、Desmin和S-100免疫组织化学染色观察,并结合文献复习分析。结果:3例肿瘤均位于皮肤表浅部位,界限较清楚,切面分叶状,质软,部分呈胶冻状。镜下肿瘤呈分叶状,间质内含较多粘液和薄壁血管并伴有少许炎细胞浸润,肿瘤细胞呈梭形和星形,无异型性。未见核分裂像。免疫组织化学染色肿瘤细胞表达Vimentin和CD34,不表达S-100和Desmin。结论:表浅性血管粘液瘤是一种少见的粘液性肿瘤,位于皮肤表浅部位,可局部复发但不转移,瘤细胞表达CD34和Vi-mentin。诊断时应注意和其它粘液性软组织肿瘤鉴别。
Objective： To study the chnicopathologic and immunohistochemical features of superficial angiomyxoma （SA） and its biologic behaviour. Methods： The pathologic feature was observed and immunohistochemical staining for Vim, CD34, Desmin and S- 100 was performed, and the relative literatures were reviewed. Results： All the tumors of the 3 cases arose in the superficial region of the skin. All of them were relatively well- circumscribed soft mass with a lobular partially tremelloid- like cut surface. Histologically, SA had a lobular appearance with prominent vascularized myxoid matrix and some inflammatory cells infiltrating in it. The tumor cells were spindle or asteroid in shape and didn, t show either nuclear atypia or mitosis. Immunohistochemical studies showed that the tumor cells were positive for Vim and CD34 and negative for S - 100 and Desmin. Conclusions： Superficial angiomyxoma is a rare myxoid tumor, and arise in the superficial region of the skin, which might recurrence locally but lack metastatic potential, the tumor cells are positive for Vimentin and CD34. The differential diagnosis of SA should include other myxoid soft tissue tumors.
出处
《华西医学》
CAS
2006年第3期479-480,共2页
West China Medical Journal
