摘要
目的探讨侵袭性血管黏液瘤的免疫组化特征和鉴别诊断。方法对发生在外阴部侵袭性血管黏液瘤4例进行组织学和免疫组化检测,以2例血管肌纤维母细胞瘤为对照。结果大阴唇3例4～6cm直径、小阴唇1例1cm直径;平均年龄36岁。复发1例。瘤细胞Vim、SMA、MSA、Des、CD34均呈阳性,ER、PR阳性细胞数>50%,Ki-67阳性指数<1%,CK和S100蛋白均阴性。结论病理形态和免疫组化明确诊断侵袭性血管黏液瘤,与血管肌纤维母细胞瘤明显重叠,两者可能属同一谱系的两种肿瘤。可能属女性生殖道下部的原始间叶细胞衍化。
Purpose To investigate the immunoprofile and differential diagnosis of aggressive angiomyxoma （AAM）. Methods Four cases of vulvar aggressive angiomyxoma were analyzed at immunohistochemical staining and study by clinicopathological feature. Results Three cases in the labia majore and one case in the labia minora of AAM,age of the patients ranged from 30 to 44 years,median 36 years,tumor＇s size in the labia minora was 1 cm diameter and in the labia majora was ranged from 4 to 6 cm diameter,recur in 1 case. Tumor cells of all cases were stained positive by Vim, SMA,MSA,Des,CD34,and ER,PR positive cells〉50%,Ki-67 positive cells〈1%. Conclusions Pathological features and immunohistochemical staining may be diagnosed by AAM, but angiomyofibroblastoma have overlapping. Both tumor are related and possibly derived from primitive mesenchymal cell in the lower female genital tract.
出处
《安徽医学》
2006年第3期187-188,共2页
Anhui Medical Journal
关键词
血管黏液瘤
免疫组化
鉴别诊断
临床病理
Angiomyxoma
lmmunoprofile
Differential diagnosis
Clinicopathology
