摘要
本文研究人体在输入７．５％氯化钠溶液后，人血浆内ｖＷｆ的变化。发现一组外科手术病人（ｎ＝１５）在输入常用剂量（４ｍｌ／ｋｇ）的高渗氯化钠溶液后，血浆ｖＷｆ有降低趋向，以输完后３０ｍｉｎ下降最明显，１２０ｍｉｎ尚未恢复正常。虽然在统计分析时无统计学意义（Ｐ＞０．０５），但结合临床观察，它可能是高渗氯化钠引起出血的原因之一。本文探讨了ｖＷｆ降低的机理，可能和内皮细胞皱缩，影响了ｖＷｆ释放有关。
he change of plasma vWf after 7 5% sodium chloride solution infusion was studied. It was found that plasma vWf tended to decrease after infusing a common dose (4ml/kg) of hyperosmotic saline, it reached a lowest point at 30 min and remained at low level at 120 min after infusion. It might be one of of the causes resulting in bleeding due to hyperosmotic saline. The mechanisms of decreased vWf after hypertonic saline infusion are discussed.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
1996年第6期310-311,共2页
Journal of Clinical Anesthesiology
