摘要
本文报告外科术中病人持续静滴普鲁卡因(PROC)的体内过程特点及其代谢产物对氨基苯甲酸(PABA)血浆内药代动力学过程以及对血液pH值及碱储的影响。用反相高效液相色谱紫外法测定仪测定血浆内普鲁卡因及对氨基苯甲酸浓度。用BGM血气分析血液pH值及碱储值,7名外科手术病人依次以1,0.7及0.5mg/kg/min的速度静滴普鲁卡因各1h后测得普鲁卡因其药时曲线表明:随着静滴普鲁卡因的时间延长,血浆内普鲁卡因浓度逐渐上升,并于停滴后一段时间内维持在较高水平,此发现与其它文献报道不相同;故本文进一步研究了普鲁卡因的药代动力学过程及病人血液pH值及碱储值的变化,结果表明;静滴普鲁卡因后由血浆胆碱酯酶水解产生的对氨基苯甲酸可使病人出现代谢性酸中毒,显著消耗碱储(p<0.01),而且碱储消耗的动态过程与普鲁卡因的过程显著相关(p<0.05)。
When seven Patients received continuous intravenous dripof PROC, the value of pH and BE in blood were observed and metabolicacidosis was confirmed. The concentration PABA by reversed phase HPLC-UV simultaneously. The longer the intravenous time, the higher the con-centration of PROC in plasma and maintaining a long time. It is differentfrom the other reports in literature. Following the intravenous drip ofPROC, the cocentration of PABA in plasma increased gradually and de-creased after stopping intravenous drip. There was a significant correlationbetween acidosis and the level of PABA in plasma.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1991年第3期186-192,共7页
The Chinese Journal of Clinical Pharmacology
关键词
普鲁卡因
药代动力学
手术
intravenous procaine
para-aminobenzoic acid
pharmacokinetics
metabolic acidosis
base excess
