期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

髓鞘相关糖蛋白与神经系统的髓鞘发育和轴突生长 被引量：4

在线阅读 下载PDF
导出
摘要 髓鞘相关糖蛋白(myelin-associated glycoprotein,MAG)是免疫球蛋白超家族成员,它由中枢神经系统的少突胶质细胞和外周神经系统的施万细胞表达。MAG定位于直接和轴突相接触的髓鞘膜的最里层,它通过介导胶质细胞与轴突的相互作用参与髓鞘的形成及其完整性的维持。同时MAG也是髓鞘来源的神经生长抑制因子的主要成分。在神经系统发育的不同阶段,MAG显示不同的功能:即发育期促进轴突生长,成熟期抑制轴突生长。其抑制作用主要由髓鞘来源的抑制分子的共同受体NgR介导,在神经营养因子受体p75NTR以及小GTP酶Rho等信号分子的共同参与下完成。
作者 顾文莉 陆佩华
机构地区 上海交通大学医学院神经生物学实验室
出处 《生理科学进展》 CAS CSCD 北大核心 2006年第3期243-246,共4页 Progress in Physiological Sciences
基金 国家重点基础研究发展计划(973)(2003CB515302) 上海市科技发展基金(02JC14014)资助课题
关键词 髓鞘相关糖蛋白 髓鞘 轴突 NOGO受体
分类号 Q291 [生物学—细胞生物学]
  • 相关文献

参考文献10

  • 1Marcus J,Dupree JL,Popko B.Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions.J Cell Biol,2002,156:567～577.
  • 2Schachner M,Bartsch U.Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin.Glia,2000,29:154～165.
  • 3Yin X,Crawford TO,Griffin JW,et al.Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons.J Neurosci,1998,18:1953～1962.
  • 4Wong EV,David S,Jacob MH,et al.Inactivation of myelin-associated glycoprotein enhances optic nerve regeneration.J Neurosci,2003,23:3112～3117.
  • 5Domeniconi M,Filbin MT.Overcoming inhibitors in myelin to promote axonal regeneration.J Neurol Sci,2005,233:43～47.
  • 6Liu BP,Fournier A,GrandPre T,et al.Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.Science,2002,297:1190～1193.
  • 7Li S,Liu BP,Budel S,et al.Blockade of Nogo-66,myelin-associated glycoprotein,and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury.J Neurosci,2004,24:10511～10520.
  • 8Venkatesh K,Chivatakarn O,Lee H,et al.The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein.J Neurosci,2005,25:808～822.
  • 9Song XY,Zhong JH,Wang X,et al.Suppression of p75NTR does not promote regeneration of injured spinal cord in mice.J Neurosci,2004,24:542～546.
  • 10Domeniconi M,Zampieri N,Spencer T,et al.MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth.Neuron,2005,46:849～855.

同被引文献30

  • 1袁普卫,贺西京.MAG蛋白在大鼠急性脊髓损伤中的表达及意义[J].陕西中医学院学报,2006,29(4):43-44. 被引量：1
  • 2李晓捷,吕智海,孙忠人,高晶.早期丰富环境刺激对脑瘫大鼠脑发育的影响[J].中国康复医学杂志,2006,21(12):1061-1064. 被引量：12
  • 3Svigos JM.The fetal inflammatory response syndrome and ce-rebral palsy:yet another challenge and dilemma for the obste-trician[J].Aust N Z J Obstet Gynaecol,2001,41(2):170-176.
  • 4Domeniconi M,Zampieri N,Spencer T,et al.MAG inducesregulated intramembrane proteolysis of the p75 neurotrophinreceptor to inhibit neurite outgrowth[J].Neuron,2005,(46):849-855.
  • 5He S,Ma J.Early enriched environment promotes neonatalGABAergic neuro-transmission and accelerates synapse matu-ration[J].Neuroscience,2010,30(23):7910-7916.
  • 6Akashimal AS,Dyck RH.Enhanced plasticity in zincergic,cortical circuits after exposure to enriched environments[J].Neuroscience,2008,28(51):13995-13999.
  • 7Yang J J, Huang S H, Chou K H, et al. Identification of mutations in members of the connexin gene family as a cause of nonsyndromic deafness in Taiwan[ J ]. Audiol Neurootol, 2007, 12(3) : 198-208.
  • 8Sohl G, Eiberger J, Jung Y T, et al. The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development[ J]. Biol Chem, 2001, 382 (6) :973-978.
  • 9Kleopa K A, Orthmann J L, Enriquez A, et al. Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in ohgodendrocytes[J]. Glia, 2004, 47(4) :346-357.
  • 10Altevogt B M, Kleopa K A, Postma F R, et al. Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems [ J ]. J Neurosci, 2002, 22(15) :6458-6470.

引证文献4

二级引证文献9

生理科学进展
2006年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部