5Costello JF,Fruhwald MC.Aberrant CpG island methylation has non-random and tumor tupe specific patterns[J].Nat Genet.,2000,24:132-138.
6Long CL,Rajvir DM.Designing primers for methylation PCRs[J].Bioinformatics,2002,18:1427-1431.
二级参考文献22
1Grady WM, Rajput A, Lutterbaugh JD, et al. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer[ J ]. Cancer Res, 2001,61 (3) :900-902.
2Herman JG, Graff JR, Myohanen S, et al. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands[ J ]. Proc Natl Acid Sci USA, 1996,93 ( 18 ) :9821-9826.
3Siah SP, Quinn DM, Bennettt GD, et al. Microsatellite instability markers in breast cancer: a review and study showing MSI was not detected at "BAT25" and "BAT26" microsatellite markers in early onset breast cancer [ J ]. Breast Cancer Res Treat, 2000,60(2) :135-142.
4Anbazhagan R, Fujii H, Gabrielson E. Microsatellite instability is unconnon in breast cancer [ J ]. Clinical Cancer Res, 1999,5(4) :839-844.
5Silva JM, Donminguez G, Garcia JM, et al. Presence of tunor DNA in plasma of breast cancer patients:clinicopathological correlations [ J ]. Cancer Res, 1999,59 ( 13 ) :3251-3256.
6Carmen J, Costa I, Conceic M,et al. Detection of gene promoter hypermethylation in fine needle washings from breast lesions [ J ].Clinical Cancer Res,2003,9 ( 9 ): 3413-3417.
7Caceres I, Battagli C, Esteller M, et al. Tumor Cell-Specific BRCA1 and RASSF1A Hypermethylation in Serum, Plasma, and Peritoneal Fluid from Ovarian Cancer Patients [ J ]. Cancer Res,2004,64( 18 ) :6476-6481.
8Bird AP. CpG-rich-island, and the function of DNA methylation[ J ]. Nature, 1986,321 ( 6067 ): 09-213.
9Jahr S, Hentze H, Englisch S, et al. DNA fragments in the blood plasma of cancer patient: quantitation and evidence for their origin from apoptotic and necrotic cells [ J ]. Cancer Res,2001,61 (4): 1659-1665.
10Stroun M, Maurice P, Vasioukhin V, et al. The origin and mechanism of circulating DNA [ J ]. Ann N Y Acad Sci ,2000,906(Apr) :161-168.
8Quina AS, Buschbeck M, Di Croce L. Chromatin structure and epigenetics [ J ]. Biochem Pharmacol, 2006,72 ( 11 ) : 1563 - 1569.
9Shen L,Kondo Y, Guo Y, et al. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters [ J ]. PLoS Genet, 2007,3 (10) :2023 - 2036.
10Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation [ J ]. N Engl J Med, 2003, 349(21 ) :2042 -2054.
