摘要
目的探讨P16和P53蛋白的表达与脑星形细胞瘤的病理组织学分级的关系。方法应用免疫组织化学技术SP法检测60例脑星形细胞瘤中P16和P53蛋白的表达情况。结果P16在脑星形细胞瘤的组织学分级Ⅲ、Ⅳ级与Ⅰ、Ⅱ级比较差异均有显著性(均P<0.05);P53在Ⅰ级脑星形细胞瘤中未见表达,与Ⅱ、Ⅲ、Ⅳ级比较差异有显著性,但Ⅱ、Ⅲ、Ⅳ级之间差异无显著性。结论P16、P53基因蛋白的表达与肿瘤的级别密切相关。
Objective To investigate the relationship between the expression of P16 and P53 in brain astrocytoma with their grading of pathological histology. Methods The expression of P16 and P53 was detected in 60 case of brain astrocytoma by S-P immunohistochemical technique. Results Among 60 brain astrocytoma,there was a significant difference between P16 and their grading of pathological histology （ P 〈 0.05 foreach ） , but the expression of P53 showed no difference in grade Ⅱ - Ⅲ, whereas there was significant difference between grade I and grade Ⅱ - Ⅳ. Conclusion The expression of P16 and P53 is closely correlated to histological grade of astrocytoma.
出处
《中国医药》
2006年第7期416-417,共2页
China Medicine
