摘要
通过综述感染人类的H5N1亚型高致病性禽流感病毒起源及演化关系,表明感染人的A/Hongkong/97(H5N1)株及目前流行的高致病性禽流感病毒可能起源于禽源的A型流感病毒株(A/Goose/Guangdong/1/96)。自1996年以来,H5N1亚型禽流感病毒的基因型经Gs/Gd,A,B,C,D,E,V,W,X0-X3,Y,Z和Z+不断的演化为目前流行的基因型Z。高致病性禽流感病毒(H5,H7和H9亚型)在禽,特别是水禽体内的重组或重配而相互传播,并随候鸟的迁徙而传播不易消灭,H5N1亚型的禽流感在不同地区的不断暴发与流行已严重威胁着养禽业的发展及人类的健康,需要进行长期监控。
In this article the author reviewed the origin and evolvement of the avian influenza virus （HSN1）. The evidence indicated that A / Hongkong / 97（HSN1）of avian influenza virus and the current epidemic trains which could infect humans originated possibly the avian influenza virus（A/Goose/Guangdong/1/ 96）. From 1996 onwards, fifteen HSN1 genotypes （Gs/Gd,A,B,C,D,E,V,W,X0-X3 ,Y,Z,Z^＋） were de- tected. The genotype Z replaced others to become dominant at present. Highly pathogenic avian influenza virus （HPAIV） involving at least three subtypes, HS, H7 and H9, can obtain the abilities of bi-directional transmission between terrestrial and aquatic poultry by gene reassortants, which could be widely spread by the migration birds in the world and are not easily eradicable. These developments pose a threat to public and poultry health in the region and potentially the world, and suggest that long-term control measures are required.
出处
《动物医学进展》
CSCD
2006年第7期24-27,共4页
Progress In Veterinary Medicine
关键词
禽流感病毒
基因型
起源
演化
Avian influenza virus
genotype
origin
evolvement
