摘要
ＤＮＡ损伤是引起基因突变，导致细胞恶性转化的重要原因．ＤＮＡ损伤的修复过程非常复杂，是与细胞周期调节、ＤＮＡ复制和ＤＮＡ转录等生命活动紧密相连的．首先ＤＮＡ修复需要细胞周期停滞，避免ＤＮＡ损伤进入子代细胞．其次，参与ＤＮＡ转录的某些基因产物参与ＤＮＡ损伤的识别，有利于转录链的优先修复．最后，ＤＮＡ修复系统ＮＥＲ、ＭＭＲ参与损伤修复．上述ＤＮＡ修复过程任何环节的异常，都将造成ＤＮＡ修复功能减弱，导致某些功能基因突变，从而导致细胞的恶性转化．
DNA damage is the cause of genemutation and contributes to cell transformation.The cellular response to DNA damage is complexin its components and regulation. First, DNArepair need cell cycle arrest to avoid mutationaccmulating in generated cell. Second, there isstrong connection between repair and transcription. Third, nucleotide excision repair and mismatch repair are important pathway of mutationavoidance. If any event mentioned above wasaltered, mutations would accumulate, and thechance of tumor developing would increase. Therelationship between DNA repair, transcriptionand the cell cycle, and the cell transformationwere discussed.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1996年第5期413-417,共5页
Progress In Biochemistry and Biophysics
关键词
肿瘤
细胞癌
DNA修复
病理
DNA repair, DNA replication, cell cycle, nucleotide excision repair, mismatch repair, neoplasm
