摘要
DNA损伤修复的过程十分复杂,主要包括切除修复途径、DNA双链断裂修复途径、错配修复途径。DNA修复功能的异常使肿瘤细胞对抗癌药物产生耐药性。利甲DNA修复的途径降低肿瘤细胞的多药耐药性将为肿瘤耐药的逆转提供新的思路。
出处
《国外医学（输血及血液学分册）》
2003年第2期125-127,共3页
Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
参考文献2
-
1Dr. Susan J. Marriott,Francene J. Lemoine,Kuan-Teh Jeang. Damaged DNA and miscounted chromosomes: Human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells[J] 2002,Journal of Biomedical Science(4):292～298
-
2Hermann Lage,Manfred Dietel. Involvement of the DNA mismatch repair system in antineoplastic drug resistance[J] 1999,Journal of Cancer Research and Clinical Oncology(3-4):156～165
同被引文献8
-
1张之南.血液病诊断和疗效标准[M].2版.北京:科学出版社,1998:373-376.
-
2Thompson l.tI, Brookman KW,Jones NJ, et al. Molecular cloning of the human XRCCI gene,which corrects defective DNA Strand Break repair and sister chromatid exchange [J]. Mol Cell Biul, 1990,10(12) :6160-6171.
-
3Cappelli E,Taylor R ,Cevasco M,et al. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair[J]. Biol Chem, 1997,272 (38) : 23970-23975.
-
4D'silva I, Pelletier JD, I.agueux J, et al. Relative affinities of poly (ADP ribose) polymerase and DNA dependent protein kinase for DNA Strand interruptions[J]. Bioehim Biophys Acta, 1999, 143( (1):119-126.
-
5Masutani M, Nozaki T, Nishiyama E, et al. Fun ction of poly( ADP ribose) polymerase in response to DNA damage:gene-disruption study in mice[J]. Mol Cell Biochem, 1999,193(1/2) :149-152.
-
6Taylor RM, Thistlethwaite A, Caldecott KW. Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair[J]. Mol Cell Biol,2002,22(8) :2556-2563.
-
7Taylor RM,Thistlethwaite A, Caldecott KW. Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair[J]. Mol Cell Biol,2002,22(8):2556-2563.
-
8Thacker J, Zdzienicka MZ. The mammalian XRCC genes: their roles in DNA repair and genetic stability [J]. DNA Repair (Amst) ,2003,2(6) :655-672.
-
1奥沙利铂/5-FU一线治疗晚期结直肠癌[J].中国处方药,2008(9):82-82.
-
2葛炜,程呤梅.急性淋巴细胞性白血病患者外周血动稚淋巴细胞...[J].浙江医学情报,1990(1):23-25.
-
3李一诗,傅仲学.姜黄素逆转肿瘤多药耐药的研究进展[J].重庆医学,2010,39(16):2225-2227. 被引量：9
-
4施为建,王渝芝,李全泳,宋浩杰,王丽,蒋凤莲,李碧霜.探讨腹腔热灌注化疗对癌性腹水多药耐药蛋白的影响[J].临床医药文献电子杂志,2016,3(15):3035-3035.
-
5刘峰,李铮.肿瘤多药耐药的研究进展[J].医学综述,2003,9(3):140-142.
-
6李洁,孙静,魏霞.半枝莲对白血病细胞株K562/A02细胞P-糖蛋白表达的影响[J].中国中医药科技,2013,20(2):139-140. 被引量：9
-
7郭姗琦,赵海丰,张翼鷟.恶性淋巴瘤的表观遗传调控与治疗[J].中华肿瘤杂志,2014,36(3):161-164. 被引量：6
-
8张代钊.对放化疗减毒增效的中药[J].东方药膳,2011(9):29-30.
-
9支学军,薛军,杨东东,薄爱华,张振忠.多药耐药蛋白与肿瘤[J].张家口医学院学报,2001,18(3):93-96.
-
10李鸣川,周宝森.XRCC1基因多态性与肺癌易感性关系的研究进展[J].肿瘤防治杂志,2004,11(4):425-428. 被引量：3
