摘要
从泰乐菌素产生菌弗氏链霉菌０２８－３菌株出发，通过ＮＴＧ多次诱变，获得一株泰乐菌素产量提高２倍以上的突变株Ｈ１８８．再以原生质体再生和原生质作诱变后再生的手段，经过连续两轮处理，获得两株突变株：Ａ１１７和Ｄ８５．在最佳发酵培养基条件下，它们的泰乐菌素产量比Ｈ１８８分别提高６．５倍和５．５倍以上．
By using the tylosin producing Streptomyces fradiae strain 028-3 as a starter,a mutant H188 with a yield of 2 times higher was obtained after three rounds of NTG mutation. After further treatments by means of protoplant regeneration and protoplast mutation,two new mutants, A117 and D85, were obtained and their yields were 6. 5 and 5. 5 times higher than that of H188,respetively.
出处
《应用与环境生物学报》
CAS
CSCD
1996年第3期315-319,共5页
Chinese Journal of Applied and Environmental Biology
