摘要
目的探讨肺炎衣原体(CP)感染对慢性阻塞性肺疾病(COPD)患者T淋巴细胞亚群的影响。方法选择上海市黄浦区中西医结合医院2001年1月至2005年1月收治的COPD急性加重期患者176例,同期正常对照组46名,为健康体检者。采用微量免疫荧光试验检测血清肺炎衣原体抗体IgG、IgA、IgM,采用流式细胞仪测定所有COPD患者和对照组的外周血CD+3、CD+4、CD+8T淋巴细胞。结果COPD急性加重期急性CP感染率为27.3%,慢性CP感染率为19.3%,与对照组比较差异有显著性意义(P0.01)。COPD患者中慢性CP感染组的CD+8细胞升高、CD+4/CD+8比值降低,较对照组差异有显著性意义,急性CP感染组和COPD肺炎衣原体阴性组的CD+8细胞及CD+4/CD+8比值与对照组差异无显者性意义。结论CP感染与COPD密切相关;CP感染是COPD急性加重的重要诱因;CP感染特别是慢性感染是引起COPD患者细胞免疫功能紊乱的重要原因,而这种细胞免疫功能的紊乱可能参与了COPD的发病。
Objective To explore the effect of Chlamydia pneumoniae （CP） infection on T lymphocyte subsets in patients with chronic obstructive pulmonary disease （COPD）. Methods A total of 176 patients with acute exacerbations of COPD who were admitted to hospital from Jan. 2001 to Jan. 2005, and 46 healthy subjects were selected. Chlamydia pneumoniae-specific serum IgG, IgA, IgM antibodies were measured by microimmunofluorescence （MIF） test; the flow cytometer was used to analyze the frequency of CD3^＋, CD4^＋ and CD8^＋ lymphocytes in patients with COPD and controls. Results The rate of acute chlamydia pneumoniae infection in COPD patients with acute exacerbations was 27.3% and that of chronic CP infection was 19. 3%. They were all significantly higher than that in healthy subjects （ P 〈 0.01 ）. The frequency of the CD3^＋ and CD4^＋ lymphocytes showed no difference in each group. The frequency of CD8^＋ lymphocyte in COPD patients of chronic CP infection rose and the CD4^＋/CD8^＋ ratio was decreased in comparison with controls. On the other hand, the CD8^＋ lymphocytes and the CD4^＋/CD8^＋ ratio showed no difference between chronic CP infection group, no CP infection group and controls. Conclusion The chlamydia pneumoniae infection is a rather frequent event in acute exacerbations of COPD, and it is an important reason to cause the disorder of cell - mediated immunity in COPD patients. The disorder of cell - mediated immunity may be involved in pathogenesis of COPD.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2006年第7期992-994,共3页
Chinese Journal of Practical Internal Medicine
关键词
肺疾病
慢性阻塞性
肺炎衣原体
T淋巴细胞亚群
Chlamydia pneumoniae
Chronic obstructive pulmonary disease
T lymphocyte subsets
