摘要
目的研究苏子降气汤对哮喘大鼠气道重塑的作用及其与肿瘤坏死因子(TNF)、内皮素(ET)含量的变化关系,以探讨苏子降气汤对哮喘大鼠气道重塑的作用机理。方法以卵白蛋白注射雾化吸入法复制哮喘大鼠模型,观察苏子降气汤对哮喘大鼠肺组织形态学,血清(浆)/肺泡灌洗液(BALF)中TNF、ET含量的影响。结果苏子降气汤对哮喘大鼠肺组织形态学具有明显的改善作用,能明显降低TNF、ET含量。结论苏子降气汤对哮喘模型气道重塑具有抑制作用,与降低哮喘模型血清(浆)/BALF中TNF、ET含量有关。
Objective To explore the mechanism of Suzijiangqi decoction to passage recombination of asthma model by studying the effect of Suzijiangqi decoction on passage recombination and the relation between it and the content of TNF and ET of asthma model. Methods Asthma model was established by OVA atomized and inhaled, the effect of Suzijiangqi decoction on the lung histomorphometric and the content of TNF and ET in serum or plasma/BALF of asthma model were observed. Results Suzijiangqi decoction obviously improved the lung histomorphometric and significantly inhibited the content of TNF and ET. Conclusion Suzijiangqi decoction can obviously control passage recombination. It is relate to inhibiting the content of TNF and ET in serum or plasma/BALF of asthma model.
出处
《中国中医药信息杂志》
CAS
CSCD
2006年第7期35-37,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
黑龙江省中医管理局资助项目(ZH04Z41)
