摘要
利用明胶的溶解性及经甲醛处理可使其固化的特性，采用改良的冷冻凝聚法，制备了包裹超微Ｆｅ３Ｏ４和平阳霉素的磁控缓释微球，避免了抗肿瘤药物在加热固化时引起的变性及降低其抗肿瘤活性。制成的微球为褐色粉末，易于保存，磁球基本为圆球形，粒径为０．７１～７．１４μｍ，粒径小，总表面积小，有助于药物释放。分散性好，可用含０．５％ｔｗｉｎ８０的生理盐水分散，流动性好，不凝聚成堆。明胶易得，价格便宜，制作工艺简便，可望广泛应用于临床。
Based on the solvability of gelatin in water and its solidification by formaldahyde, a modified cold condensation method was used to prepare the gelatin PYM magnetic microspheres which entrap Fe 3O 4 and pingyangmycin (PYM). The preparation is a kind of brown powder and the microspheres are spherical with the diameter of 0.71～7.14 μm. It can be very well decentralized in 0.9% NaCl containing 0.5% twin 80 with good fluidity and without condensation and accumulation. The magnetic microspheres are easy to be prepared and preserved.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1996年第3期220-222,共3页
West China Journal of Stomatology
