摘要
本实验观察了体外循环下心内直视手术患者血清乳酸脱氢酶(LDH)、肌酸激酶(CK)活性的变化及复方丹参对其的作用。20例室缺或房缺病人,心功能分级(ASA,Ⅱ~Ⅲ级),麻醉后随机分为对照组(组Ⅰ,n=10)及复方丹参治疗组(组Ⅱ,n=10)。组Ⅱ于手术前及复温后心脏复跳前分别静注复方丹参200mg/kg。结果表明;组Ⅰ缺血(T2)及再灌注后各期血清LDH、CK与术前(T0)比较显著增高,与组Ⅱ各时期值差异显著,且术后心功能恢复较组Ⅱ差。组ⅡT2时LDH及CK与T0比较差异无显著性,再灌注30min后才有明显上升,但显著低于组Ⅰ(P<001)。本实验结果显示复方丹参能明显降低心内直视手术患者血清LDH及CK活性,减轻心肌缺血再灌注损伤程度。
The serum LDH and CK activities and the effects of salvia miltiorrhizae compound(SMC)were observed in patients undergoing cardiopulmonary bypass(CPB).20 patients with eitherVSD or ASD,ASA grade 2~3,were divided randomly into group 1(n=I0,as control)andgroup 2(n=10,as the treated group).Before operation and at the time of rewarming,patientsin group 2 were administered intravenously with salvia Miltiorrhizae at a dosage of 200 mg/kgat either time.The results showed that serum LDH,CK significantly increased in group 1 afterischemia(T2)and reperfusion as compared with its pre-operative(To)value.The serum LDHand CK value at T2 were not evidently different from its to value in group 2.Significant LDH,CK increase did not appeared until after 30 min of reperfusion in group 2,and the values weresignificantly lower than those in group 1.The post-operative heart function recovery of group 2was better than that in group 1.The results indicate that SMC can significantly reduce theserum LDH and CK activity increase in patients undergoing intracardiac surgery and attenuateheart ischemia/reperfusion injury.
作者
夏正远
顾家珍
史昕云
吴先平
黄海波
余金甫
Xia Zhengyuan;Gu Jiazheng;Shi Xinyun(Department of Anesthesiology,First Affiliated Hospital,Hubei Medicaluniversity,Wuhan 430060,China)
关键词
心内直视手术
心肌缺血
再灌注
心肌酶
myocardium/EN
plants,medicinal
hemoperfusion
heart surgery
