摘要
目的观察酒速愈对急性酒精中毒小鼠肝组织肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)的影响。方法采用56°白酒灌胃建立急性酒精中毒小鼠模型,以葛花解醒汤为对照,给药后检测各组小鼠肝组织TNF-α、IL-8含量。结果与正常组比较,模型组小鼠肝组织TNF-α、IL-8明显升高;与模型组比较,酒速愈高、低剂量组均可明显降低小鼠肝组织TNF-α、IL-8含量,葛花解醒汤组可明显降低小鼠肝组织IL-8含量;与葛花解醒汤组比较,酒速愈高剂量组小鼠肝组织TNF-α含量明显降低。结论酒速愈能够通过降低肝组织TNF-α、IL-8含量,减轻急性酒精中毒时肝脏的炎性损伤。
Objective:To observe the effect of Jiusuyu(酒速愈) on TNF-α,IL-8 in the liver tissue of acute alcoholism mice.Methods:To make the model of acute alcoholism mice by drinking 56°drink,compared with Gehuajiexing Decoction(葛花解醒汤),and test the content of TNF-α,IL-8 in each group.Results:Compared with normal group,the content of TNF-α,IL-8 in the liver tissue of the model group were increased.Compared with model group,the content of TNF-α,IL-8 in liver tissue of Jiusuyu high-dose and low-dose group were decreased,the content of IL-8 in liver tissue of Gehuajiecheng Decoction group were decreased.Compared with Gehuajiecheng Decoction group,the content of TNF-αin liver tissue of Jiusuyu high-dose group were decreased.Conclusion:Jiusuyu could relieve the injury of the liver tissue from acute alcoholism by decreasing the contert of TNF-α,IL-8 in liver tissue.
出处
《中国中医急症》
2006年第7期760-761,共2页
Journal of Emergency in Traditional Chinese Medicine
基金
河北省自然基金委员会资助项目(No.C2005000690)
